| Gene Symbol |
CTSK
|
| Entrez Gene |
1513
|
| Alt Symbol |
CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cathepsin K
|
| Other Description |
cathepsin O|cathepsin O1|cathepsin O2|cathepsin X
|
| Swissprots |
Q6FHS6 P43235
|
| Accessions |
ABB80374 ABB80375 ABB80376 BAL72530 EAW53515 EAW53516 P43235 AK130134 AK308229 AK312880 AU118043 AU119985 AW631268 AY429530 BC016058 AAH16058 CR541675 CAG46476 CR541719 CAG46520 DA251123 HQ447237 ADQ31724 S79895 AAB35521 U13665 AAA65233 U20280 AAA95998 NM_000396 NP_000387
|
| Function |
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
|
| Subcellular Location |
Lysosome.
|
| Tissue Specificity |
Predominantly expressed in osteoclasts (bones).
|
| Top Pathways |
Toll-like receptor signaling pathway, Lysosome, Osteoclast differentiation, Rheumatoid arthritis
|