Gene Symbol | CTSK |
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Entrez Gene | 1513 |
Alt Symbol | CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD |
Species | Human |
Gene Type | protein-coding |
Description | cathepsin K |
Other Description | cathepsin O|cathepsin O1|cathepsin O2|cathepsin X |
Swissprots | Q6FHS6 P43235 |
Accessions | ABB80374 ABB80375 ABB80376 BAL72530 EAW53515 EAW53516 P43235 AK130134 AK308229 AK312880 AU118043 AU119985 AW631268 AY429530 BC016058 AAH16058 CR541675 CAG46476 CR541719 CAG46520 DA251123 HQ447237 ADQ31724 S79895 AAB35521 U13665 AAA65233 U20280 AAA95998 NM_000396 NP_000387 |
Function | Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. |
Subcellular Location | Lysosome. |
Tissue Specificity | Predominantly expressed in osteoclasts (bones). |
Top Pathways | Toll-like receptor signaling pathway, Lysosome, Osteoclast differentiation, Rheumatoid arthritis |
cathepsin K (E-7) - sc-48353 from Santa Cruz Biotechnology
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cathepsin K (H-50) - sc-30056 from Santa Cruz Biotechnology
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cathepsin K (N-20) - sc-6507 from Santa Cruz Biotechnology
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cathepsin K (C-16) - sc-6506 from Santa Cruz Biotechnology
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pan cathepsin (D-2) - sc-377017 from Santa Cruz Biotechnology
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pan cathepsin (H-1) - sc-376803 from Santa Cruz Biotechnology
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pan cathepsin (N-20) - sc-6499 from Santa Cruz Biotechnology
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Anti-Cathepsin K antibody - ab19027 from Abcam
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Anti-Cathepsin K antibody - ab188604 from Abcam
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Anti-Cathepsin K antibody - ab49892 from Abcam
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Anti-Cathepsin K antibody [2F1] - ab119293 from Abcam
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Anti-Cathepsin K antibody [3F9] - ab37259 from Abcam
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Anti-Cathepsin K antibody [EP9403] - ab187647 from Abcam
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Anti-Cathepsin K antibody - Catalytic domain - ab49893 from Abcam
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Anti-Cathepsin K antibody - N-terminal - ab157140 from Abcam
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Anti-Cathepsin W [EPR15135] antibody - ab191083 from Abcam
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Anti-Cathepsin W [EPR15136] antibody - C-terminal - ab191082 from Abcam
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Anti-Cathepsin W antibody - ab50550 from Abcam
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Anti-Cathepsin W antibody - ab50551 from Abcam
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Anti-Cathepsin W antibody [BV39-2B] - ab24529 from Abcam
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Anti-Procathepsin K antibody - ab39245 from Abcam
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Anti-Procathepsin K antibody [4b9] - ab39246 from Abcam
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Anti-CTSK / Cathepsin K Antibody - LS-C334355 from LifeSpan Bioscience
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Anti-CTSK / Cathepsin K Antibody (aa1-101) IHC-plus™ - LS-B11598 from LifeSpan Bioscience
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Anti-CTSK / Cathepsin K Antibody (clone 2F1) IHC-plus™ - LS-B4308 from LifeSpan Bioscience
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