| Gene Symbol |
ACTN2
|
| Entrez Gene |
88
|
| Alt Symbol |
CMD1AA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
actinin, alpha 2
|
| Other Description |
F-actin cross-linking protein|alpha-actinin skeletal muscle|alpha-actinin-2
|
| Swissprots |
B1ANE4 P35609 Q86TF4 B2RCS5 Q86TI8
|
| Accessions |
AAA51584 CAB61269 EAW70064 EAW70065 P35609 AB209521 BAD92758 AK294906 BAH11921 AK297469 BAH12587 AK297618 BAH12632 AK297628 BAH12634 AK297886 BAH12687 AK315250 BAG37672 BC047901 AAH47901 BC051770 AAH51770 BX103017 CB153006 DC378038 M86406 AAA51583 NM_001103 NP_001094 NM_001278343 NP_001265272 NM_001278344 NP_001265273
|
| Function |
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
|
| Subcellular Location |
Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11171996, ECO:0000269|PubMed:19932097}. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
|
| Tissue Specificity |
Expressed in both skeletal and cardiac muscle.
|
| Top Pathways |
Systemic lupus erythematosus, Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Leukocyte transendothelial migration, Amoebiasis
|