Gene Symbol | FBN3 |
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Entrez Gene | 84467 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | fibrillin 3 |
Other Description | fibrillin-3 |
Swissprots | Q96JP8 Q75N91 Q86SJ5 Q75N93 Q75N90 Q75N92 |
Accessions | BAD16733 BAD16734 BAD16735 BAD16736 EAW68946 EAW68947 EAW68948 Q75N90 AB053450 BAB47408 AI341180 AK000036 AK074501 AK095563 BAG53085 AK096539 BAG53318 AK131282 BAD18457 AY165863 AAO18145 AY165864 AAO18146 AY165865 AAO18147 BC153882 AAI53883 CD634017 CN369190 XM_011528373 XP_011526675 NM_032447 NP_115823 |
Function | Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin- containing microfibrils provide long-term force bearing structural support. {ECO:0000269|PubMed:14962672}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14962672}. |
Tissue Specificity | Predominantly expressed in connective tissues such as skeletal muscle, tendon, skin, perichondrium and periosteum. Highly expressed in fetal lung, brain, kidney. Expressed at low level in prostate, testis, mammary gland, uterus, ovary, placenta, bladder, adrenal gland, thyroid, fetal thymus, fetal liver, liver, fetal heart and heart. {ECO:0000269|PubMed:14962672}. |
fibrillin-3 CRISPR/Cas9 KO Plasmid (h) - sc-408298 from Santa Cruz Biotechnology
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fibrillin-3 HDR Plasmid (h) - sc-408298-HDR from Santa Cruz Biotechnology
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fibrillin-3 Double Nickase Plasmid (h) - sc-408298-NIC from Santa Cruz Biotechnology
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fibrillin-3 Double Nickase Plasmid (h2) - sc-408298-NIC-2 from Santa Cruz Biotechnology
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fibrillin-3 CRISPR Activation Plasmid (h) - sc-408298-ACT from Santa Cruz Biotechnology
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fibrillin-3 CRISPR Activation Plasmid (h2) - sc-408298-ACT-2 from Santa Cruz Biotechnology
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fibrillin-3 Lentiviral Activation Particles (h) - sc-408298-LAC from Santa Cruz Biotechnology
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fibrillin-3 Lentiviral Activation Particles (h2) - sc-408298-LAC-2 from Santa Cruz Biotechnology
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fibrillin-3 siRNA (h) - sc-97083 from Santa Cruz Biotechnology
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fibrillin-3 shRNA Plasmid (h) - sc-97083-SH from Santa Cruz Biotechnology
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fibrillin-3 shRNA (h) Lentiviral Particles - sc-97083-V from Santa Cruz Biotechnology
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FBN3 RNAi - H00084467-R01 from Novus Biologicals
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MISSION® esiRNA - EHU068531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8510 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8510 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04286 from Sigma-Aldrich
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FBN3 siRNA (Human) - CRJ3493 from Cohesion Biosciences
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FBN3 - MBS8233049 from MyBioSource
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shRNA set against Human FBN3 (NM_032447.3) - SHH292761 from Creative biogene
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FBN3 shRNA Plasmid (Human) - CHJ3493 from Cohesion Biosciences
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FBN3 miRNA 3'UTR clone - MiUTR1H-03535 from Creative biogene
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