| Gene Symbol | CHIT1 |
|---|---|
| Entrez Gene | 1118 |
| Alt Symbol | CHI3, CHIT, CHITD |
| Species | Human |
| Gene Type | protein-coding |
| Description | chitinase 1 (chitotriosidase) |
| Other Description | chitotriosidase-1|plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase |
| Swissprots | Q0VGG6 B3KNW6 Q9H3V8 Q0VGG5 Q13231 Q6ISC2 Q9UDJ8 J3KN09 Q3ZAR1 |
| Accessions | EAW91469 EAW91470 EAW91471 Q13231 AI697695 AK055165 BAG51478 AK131093 BAC85143 AK225245 AK309341 AK314331 BC069614 AAH69614 BC103695 AAI03696 BC105680 AAI05681 BC105681 AAI05682 BC105682 AAI05683 BP297140 BP304256 BQ029424 BX096812 BX099272 U29615 AAC50246 U62662 AAG10644 XM_011509109 XP_011507411 XM_011509110 XP_011507412 XR_921732 NM_001256125 NP_001243054 NM_001270509 NP_001257438 NM_003465 NP_003456 NR_045784 NR_045785 |
| Function | Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. {ECO:0000269|PubMed:7592832, ECO:0000269|PubMed:7836450}. |
| Subcellular Location | Secreted. Lysosome. Note=A small proportion is lysosomal. |
| Tissue Specificity | Detected in spleen. Secreted by cultured macrophages. {ECO:0000269|PubMed:7836450}. |
| Top Pathways | Amino sugar and nucleotide sugar metabolism |