Gene Symbol | CHIT1 |
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Entrez Gene | 1118 |
Alt Symbol | CHI3, CHIT, CHITD |
Species | Human |
Gene Type | protein-coding |
Description | chitinase 1 (chitotriosidase) |
Other Description | chitotriosidase-1|plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase |
Swissprots | Q0VGG6 B3KNW6 Q9H3V8 Q0VGG5 Q13231 Q6ISC2 Q9UDJ8 J3KN09 Q3ZAR1 |
Accessions | EAW91469 EAW91470 EAW91471 Q13231 AI697695 AK055165 BAG51478 AK131093 BAC85143 AK225245 AK309341 AK314331 BC069614 AAH69614 BC103695 AAI03696 BC105680 AAI05681 BC105681 AAI05682 BC105682 AAI05683 BP297140 BP304256 BQ029424 BX096812 BX099272 U29615 AAC50246 U62662 AAG10644 XM_011509109 XP_011507411 XM_011509110 XP_011507412 XR_921732 NM_001256125 NP_001243054 NM_001270509 NP_001257438 NM_003465 NP_003456 NR_045784 NR_045785 |
Function | Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. {ECO:0000269|PubMed:7592832, ECO:0000269|PubMed:7836450}. |
Subcellular Location | Secreted. Lysosome. Note=A small proportion is lysosomal. |
Tissue Specificity | Detected in spleen. Secreted by cultured macrophages. {ECO:0000269|PubMed:7836450}. |
Top Pathways | Amino sugar and nucleotide sugar metabolism |
Chitotriosidase CRISPR/Cas9 KO Plasmid (h) - sc-402112 from Santa Cruz Biotechnology
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Chitotriosidase HDR Plasmid (h) - sc-402112-HDR from Santa Cruz Biotechnology
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Chitotriosidase Double Nickase Plasmid (h) - sc-402112-NIC from Santa Cruz Biotechnology
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Chitotriosidase Double Nickase Plasmid (h2) - sc-402112-NIC-2 from Santa Cruz Biotechnology
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Chitotriosidase CRISPR Activation Plasmid (h) - sc-402112-ACT from Santa Cruz Biotechnology
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Chitotriosidase CRISPR Activation Plasmid (h2) - sc-402112-ACT-2 from Santa Cruz Biotechnology
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Chitotriosidase Lentiviral Activation Particles (h) - sc-402112-LAC from Santa Cruz Biotechnology
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Chitotriosidase Lentiviral Activation Particles (h2) - sc-402112-LAC-2 from Santa Cruz Biotechnology
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Chitotriosidase siRNA (h) - sc-60365 from Santa Cruz Biotechnology
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Chitotriosidase shRNA Plasmid (h) - sc-60365-SH from Santa Cruz Biotechnology
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Chitotriosidase shRNA (h) Lentiviral Particles - sc-60365-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU157041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6061 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01165 from Sigma-Aldrich
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CHIT1 siRNA (Human) - CRH0798 from Cohesion Biosciences
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CHIT1 - MBS8210580 from MyBioSource
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shRNA set against Human CHIT1 (NM_003465.2) - SHH263097 from Creative biogene
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Human CHIT1 siRNA - orb261300 from Biorbyt
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CHIT1 shRNA Plasmid (Human) - CHH0798 from Cohesion Biosciences
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CHIT1 miRNA 3'UTR clone - MiUTR3H-03086 from Creative biogene
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