| Gene Symbol |
ITGA9
|
| Entrez Gene |
3680
|
| Alt Symbol |
ALPHA-RLC, ITGA4L, RLC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, alpha 9
|
| Other Description |
integrin alpha-9|integrin alpha-RLC
|
| Swissprots |
Q13797 Q14638
|
| Accessions |
CCQ43170 EAW64501 Q13797 AK026826 AK123884 BC030198 AAH30198 BX647350 D25303 BAA04984 L24158 AAA16099 NM_002207 NP_002198
|
| Function |
Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E- I-D-G-I-E-L in cytotactin. {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
|
| Tissue Specificity |
In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers. {ECO:0000269|PubMed:8245132, ECO:0000269|PubMed:8290272}.
|
| Top Pathways |
Focal adhesion, ECM-receptor interaction, Cell adhesion molecules (CAMs), Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC)
|