Gene Symbol | MRPL18 |
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Entrez Gene | 29074 |
Alt Symbol | HSPC071, L18mt, MRP-L18 |
Species | Human |
Gene Type | protein-coding |
Description | mitochondrial ribosomal protein L18 |
Other Description | 39S ribosomal protein L18, mitochondrial |
Swissprots | Q9NZW8 Q5TAP9 Q9H0U6 |
Accessions | EAW47614 EAW47615 Q9H0U6 AF161556 AAF29043 AK311391 AL136633 CAB66568 AM393775 CAL38650 BC001623 AAH01623 BU932963 CB529016 CR533491 CAG38522 XM_006715466 XP_006715529 NM_014161 NP_054880 |
Function | Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA. {ECO:0000269|PubMed:21685364}. |
Subcellular Location | Mitochondrion. |
Top Pathways | Ribosome |
MRP-L18 CRISPR/Cas9 KO Plasmid (h) - sc-409905 from Santa Cruz Biotechnology
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MRP-L18 HDR Plasmid (h) - sc-409905-HDR from Santa Cruz Biotechnology
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MRP-L18 Double Nickase Plasmid (h) - sc-409905-NIC from Santa Cruz Biotechnology
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MRP-L18 Double Nickase Plasmid (h2) - sc-409905-NIC-2 from Santa Cruz Biotechnology
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MRP-L18 CRISPR Activation Plasmid (h) - sc-409905-ACT from Santa Cruz Biotechnology
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MRP-L18 CRISPR Activation Plasmid (h2) - sc-409905-ACT-2 from Santa Cruz Biotechnology
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MRP-L18 Lentiviral Activation Particles (h) - sc-409905-LAC from Santa Cruz Biotechnology
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MRP-L18 Lentiviral Activation Particles (h2) - sc-409905-LAC-2 from Santa Cruz Biotechnology
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MRP-L18 siRNA (h) - sc-95080 from Santa Cruz Biotechnology
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MRP-L18 shRNA Plasmid (h) - sc-95080-SH from Santa Cruz Biotechnology
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MRP-L18 shRNA (h) Lentiviral Particles - sc-95080-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU118811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14553 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14553 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02828 from Sigma-Aldrich
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MRPL18 siRNA (Human) - CRH9171 from Cohesion Biosciences
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shRNA set against Human MRPL18 (NM_014161.3) - SHH344604 from Creative biogene
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MRPL18 shRNA Plasmid (Human) - CHH9171 from Cohesion Biosciences
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MRPL18 miRNA 3'UTR clone - MiUTR3H-12134 from Creative biogene
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