Gene Symbol | GGCX |
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Entrez Gene | 2677 |
Alt Symbol | VKCFD1 |
Species | Human |
Gene Type | protein-coding |
Description | gamma-glutamyl carboxylase |
Other Description | peptidyl-glutamate 4-carboxylase|vitamin K-dependent gamma-carboxylase |
Swissprots | Q6GU45 B4DMC5 P38435 E9PEE1 Q14415 |
Accessions | AAB39832 AAF64245 AAY24340 ABV02114 EAW99509 EAW99510 P38435 AK054569 AK130139 AK222827 BAD96547 AK225663 AK297397 BAG59837 AK298982 BAG61076 AK310483 AK313126 BAG35946 BC004422 BC013979 AAH13979 BM974022 DC296316 DQ892948 ABM83874 DQ896196 ABM87195 EU847509 ACF70731 L17128 AAA91834 M81592 AAA58643 XM_005264259 XP_005264316 XM_011532764 XP_011531066 XM_011532765 XP_011531067 XR_939677 NM_000821 NP_000812 NM_001142269 NP_001135741 |
Function | Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. {ECO:0000269|PubMed:17073445}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10910912}; Multi-pass membrane protein {ECO:0000269|PubMed:10910912}. |
Top Pathways | Ubiquinone and other terpenoid-quinone biosynthesis |
Human GGCX protein fragment - ab114658 from Abcam
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GGCX Antibody Blocking Peptide - LS-E761 from LifeSpan Bioscience
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GGCX Antibody Blocking Peptide - LS-E16288 from LifeSpan Bioscience
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GGCX Antibody Blocking Peptide - LS-E27105 from LifeSpan Bioscience
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GGCX Partial Recombinant Protein - H00002677-Q01 from Novus Biologicals
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GGCX-Antibody-Center-Blocking-peptide - BP11117c from Abgent, a WuXi AppTec company
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GGCX blocking peptide - GTX88337-PEP from GeneTex
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GGCX Blocking Peptide - 33R-2973 from Fitzgerald
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GGCX Peptide - AC21-1927-P from Abcore
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GGCX - H00002677-Q01 from Acris Antibodies
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GGCX Peptide - 42-100P from ProSci
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GGCX fusion protein - Ag9185 from Proteintech Group
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GGCX fusion protein - ag9261 from Proteintech Group
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Recombinant Human GGCX - GGCX-29018TH from Creative Biomart
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Recombinant Human GGCX, GST-tagged - GGCX-13240H from Creative Biomart
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Recombinant Human Vitamin K-dependent gamma-carboxylase(GGCX) - CSB-YP009388HU CSB-EP009388HU CSB-BP009388HU CSB-MP009388HU from Cusabio
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Vitamin K-dependent gamma-carboxylase (GGCX), Recombinant Protein - MBS958004 from MyBioSource
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GGCX, Peptide - MBS426844 from MyBioSource
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GGCX Recombinant Protein Antigen - NBP1-80624PEP from Novus Biologicals
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GGCX Peptide, Human - M34GP06232H from Creative Peptides
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