| Gene Symbol |
ABHD6
|
| Entrez Gene |
57406
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
abhydrolase domain containing 6
|
| Other Description |
2-arachidonoylglycerol hydrolase|abhydrolase domain-containing protein 6|lipase protein|monoacylglycerol lipase ABHD6
|
| Swissprots |
Q6ZMF7 B2R7Y9 Q9BV23
|
| Accessions |
CAC39533 EAW65360 EAW65361 EAW65362 EAW65363 EAW65364 EAW65365 Q9BV23 AF225418 AAG09720 AK092841 AK122983 BAG53832 AK172797 BAD18771 AK225942 AK313168 BAG35986 BC001698 AAH01698 DA266414 XM_005265334 XP_005265391 XM_005265335 XP_005265392 XM_005265336 XP_005265393 NM_020676 NP_065727
|
| Function |
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). {ECO:0000250|UniProtKB:Q8R2Y0, ECO:0000269|PubMed:22969151}.
|
| Subcellular Location |
Membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein {ECO:0000255}. Mitochondrion {ECO:0000250|UniProtKB:Q8R2Y0}.
|
| Top Pathways |
Retrograde endocannabinoid signaling
|
![Western Blot: ABHD6 Overexpression Lysate (Adult Normal) [NBL1-07200] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ABHD6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/806_ABHD6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07200-img0002.jpg)