Gene Symbol | ABHD6 |
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Entrez Gene | 57406 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | abhydrolase domain containing 6 |
Other Description | 2-arachidonoylglycerol hydrolase|abhydrolase domain-containing protein 6|lipase protein|monoacylglycerol lipase ABHD6 |
Swissprots | Q6ZMF7 B2R7Y9 Q9BV23 |
Accessions | CAC39533 EAW65360 EAW65361 EAW65362 EAW65363 EAW65364 EAW65365 Q9BV23 AF225418 AAG09720 AK092841 AK122983 BAG53832 AK172797 BAD18771 AK225942 AK313168 BAG35986 BC001698 AAH01698 DA266414 XM_005265334 XP_005265391 XM_005265335 XP_005265392 XM_005265336 XP_005265393 NM_020676 NP_065727 |
Function | Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). {ECO:0000250|UniProtKB:Q8R2Y0, ECO:0000269|PubMed:22969151}. |
Subcellular Location | Membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein {ECO:0000255}. Mitochondrion {ECO:0000250|UniProtKB:Q8R2Y0}. |
Top Pathways | Retrograde endocannabinoid signaling |
ABHD6 CRISPR/Cas9 KO Plasmid (h) - sc-405114 from Santa Cruz Biotechnology
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ABHD6 HDR Plasmid (h) - sc-405114-HDR from Santa Cruz Biotechnology
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ABHD6 Double Nickase Plasmid (h) - sc-405114-NIC from Santa Cruz Biotechnology
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ABHD6 Double Nickase Plasmid (h2) - sc-405114-NIC-2 from Santa Cruz Biotechnology
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ABHD6 CRISPR Activation Plasmid (h) - sc-405114-ACT from Santa Cruz Biotechnology
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ABHD6 CRISPR Activation Plasmid (h2) - sc-405114-ACT-2 from Santa Cruz Biotechnology
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ABHD6 Lentiviral Activation Particles (h) - sc-405114-LAC from Santa Cruz Biotechnology
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ABHD6 Lentiviral Activation Particles (h2) - sc-405114-LAC-2 from Santa Cruz Biotechnology
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ABHD6 siRNA (h) - sc-77911 from Santa Cruz Biotechnology
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ABHD6 shRNA Plasmid (h) - sc-77911-SH from Santa Cruz Biotechnology
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ABHD6 shRNA (h) Lentiviral Particles - sc-77911-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU079531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2667 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2667 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07766 from Sigma-Aldrich
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ABHD6 siRNA (Human) - CRJ1433 from Cohesion Biosciences
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ABHD6 - MBS8221353 from MyBioSource
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shRNA set against Human ABHD6 (NM_020676.5) - SHH229550 from Creative biogene
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ABHD6 shRNA Plasmid (Human) - CHJ1433 from Cohesion Biosciences
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ABHD6 miRNA 3'UTR clone - MiUTR3H-13493 from Creative biogene
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