Gene Symbol | NSUN4 |
---|---|
Entrez Gene | 387338 |
Alt Symbol | SHTAP |
Species | Human |
Gene Type | protein-coding |
Description | NOP2/Sun domain family, member 4 |
Other Description | 5-methylcytosine rRNA methyltransferase NSUN4|NOL1/NOP2/Sun domain family member 4|putative methyltransferase NSUN4|sperm head and tail associated protein |
Swissprots | B3KQ50 Q5TDF7 Q9HAJ8 Q96AN8 A8K6S6 Q96CB9 B4DHA4 |
Accessions | EAX06917 EAX06920 Q96CB9 AK021577 BAB13847 AK057420 BAG51912 AK097524 BAG53482 AK128066 BAC87258 AK291741 BAF84430 AK292353 BAF85042 AK295003 BAG58065 AK311009 BC014441 AAH14441 BC016907 AAH16907 BE542166 BG821302 BM153143 BM665392 BM888153 BM994678 BU536211 BX360729 BX648592 CF593490 DA799314 DA905308 NM_001256127 NP_001243056 NM_001256128 NP_001243057 NM_199044 NP_950245 NR_045789 NR_045790 NR_045791 |
Function | Involved in mitochondrial ribosome assembly. 5- methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4. {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:23022348}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:22949673, ECO:0000269|PubMed:23022348}. |
NSUN4 CRISPR/Cas9 KO Plasmid (h) - sc-415742 from Santa Cruz Biotechnology
|
||||||||
NSUN4 HDR Plasmid (h) - sc-415742-HDR from Santa Cruz Biotechnology
|
||||||||
NSUN4 Double Nickase Plasmid (h) - sc-415742-NIC from Santa Cruz Biotechnology
|
||||||||
NSUN4 Double Nickase Plasmid (h2) - sc-415742-NIC-2 from Santa Cruz Biotechnology
|
||||||||
NSUN4 CRISPR Activation Plasmid (h) - sc-415742-ACT from Santa Cruz Biotechnology
|
||||||||
NSUN4 CRISPR Activation Plasmid (h2) - sc-415742-ACT-2 from Santa Cruz Biotechnology
|
||||||||
NSUN4 Lentiviral Activation Particles (h) - sc-415742-LAC from Santa Cruz Biotechnology
|
||||||||
NSUN4 Lentiviral Activation Particles (h2) - sc-415742-LAC-2 from Santa Cruz Biotechnology
|
||||||||
NSUN4 siRNA (h) - sc-75966 from Santa Cruz Biotechnology
|
||||||||
NSUN4 shRNA Plasmid (h) - sc-75966-SH from Santa Cruz Biotechnology
|
||||||||
NSUN4 shRNA (h) Lentiviral Particles - sc-75966-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU057471 from Sigma-Aldrich
|
||||||||
MISSION® esiRNA - EHU146841 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN15540 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15540 from Sigma-Aldrich
|
||||||||
NSUN4 siRNA (Human) - CRJ7736 from Cohesion Biosciences
|
||||||||
shRNA set against Human NSUN4 (NM_199044.3) - SHH355452 from Creative biogene
|
||||||||
NSUN4 shRNA Plasmid (Human) - CHJ7736 from Cohesion Biosciences
|
||||||||
NSUN4 miRNA 3'UTR clone - MiUTR4H-TG06147 from Creative biogene
|