PDGFC

Gene Symbol PDGFC
Entrez Gene 56034
Alt Symbol FALLOTEIN, SCDGF
Species Human
Gene Type protein-coding
Description platelet derived growth factor C
Other Description PDGF-C|VEGF-E|platelet-derived growth factor C|secretory growth factor-like protein|spinal cord-derived growth factor
Swissprots Q9UL22 Q4W5M9 B9EGR8 B4DU34 Q9NRA1
Accessions AAY40906 CAH23469 CAI58839 CAI93202 CAL33851 CAL60145 CAT16763 EAX04874 EAX04875 Q9NRA1 AB033831 BAB03266 AF091434 AAF00049 AF244813 AAF80597 AF260738 AAK51637 AI446155 AK300480 BAG62196 AK304638 BAG65417 AK313817 BAG36553 AM922296 CAP58278 AY358493 AAQ88857 BC041783 BC051876 BC094746 BC136662 AAI36663 BC144348 XM_011532124 XP_011530426 XM_011532125 XP_011530427 NM_016205 NP_057289 NR_036641
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additiona
Subcellular Location Cytoplasm. Secreted. Nucleus. Cytoplasmic granule. Note=Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors.
Tissue Specificity Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes. {ECO:0000269|PubMed:10806482, ECO:0000269|PubMed:11004490, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11342471, ECO:0000269|PubMed:11854040, ECO:0000269|PubMed:12176024, ECO:0000269|PubMed:15061151, ECO:0000269|PubMed:17482170, ECO:0000269|PubMed:18055825}.
Top Pathways Rap1 signaling pathway, Cytokine-cytokine receptor interaction, Choline metabolism in cancer, PI3K-Akt signaling pathway, Prostate cancer

PDGF-C (C-17) - sc-18228 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDGF-C (C-17): sc-18228. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse uterus tissue showing membrane and extracellular localization.

PDGF-C (H-125) - sc-33190 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDGF-C (H-125): sc-33190. Western blot analysis of PDGF-C expression in MDA-MB-231 whole cell lysate (A) and mouse colon (B) and mouse prostate (C) tissue extracts.

PDGF-C (T-20) - sc-23555 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PDGFC antibody - ab200401 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling PDGFC with ab200401 at 1/40 dilution.

Anti-PDGFC antibody - ab93899 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PDGFC antibody (ab93899) at 1 µg/ml + Human Platelet (Human adult normal cell line) Whole Cell Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PDGFC antibody - ab112915 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PDGFC antibody (ab112915) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

Anti-PDGF-CC Antibody (N-Terminus) IHC-plus™ - LS-B11979 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-PDGF-CC Antibody (aa81-96) - LS-C3151 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody - LS-C150225 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PDGF-CC Antibody - LS-C136913 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa80-110, AP) - LS-C265922 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa80-110, APC) - LS-C265923 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa80-110, Biotin) - LS-C265925 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa80-110, Azide-free, HRP) - LS-C265927 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa80-110, FITC) - LS-C265926 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa80-110, PE) - LS-C265928 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa235-345, Biotin) - LS-C300437 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa235-345, FITC) - LS-C303826 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody - LS-C136914 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa23-345, Biotin) - LS-C300439 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa80-110) - LS-C323899 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa23-345, FITC) - LS-C303827 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDGF-CC Antibody (aa250-299) - LS-C186714 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Fetal Liver. PDGFC antibody dilution 1.0 ug/ml.

Anti-PDGF-CC Antibody (aa23-345) - LS-C295956 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PDGFC.

Anti-PDGF-CC Antibody (aa235-345) - LS-C295955 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PDGFC.
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