PDGFC
| Gene Symbol | PDGFC |
|---|---|
| Entrez Gene | 56034 |
| Alt Symbol | FALLOTEIN, SCDGF |
| Species | Human |
| Gene Type | protein-coding |
| Description | platelet derived growth factor C |
| Other Description | PDGF-C|VEGF-E|platelet-derived growth factor C|secretory growth factor-like protein|spinal cord-derived growth factor |
| Swissprots | Q9UL22 Q4W5M9 B9EGR8 B4DU34 Q9NRA1 |
| Accessions | AAY40906 CAH23469 CAI58839 CAI93202 CAL33851 CAL60145 CAT16763 EAX04874 EAX04875 Q9NRA1 AB033831 BAB03266 AF091434 AAF00049 AF244813 AAF80597 AF260738 AAK51637 AI446155 AK300480 BAG62196 AK304638 BAG65417 AK313817 BAG36553 AM922296 CAP58278 AY358493 AAQ88857 BC041783 BC051876 BC094746 BC136662 AAI36663 BC144348 XM_011532124 XP_011530426 XM_011532125 XP_011530427 NM_016205 NP_057289 NR_036641 |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additiona |
| Subcellular Location | Cytoplasm. Secreted. Nucleus. Cytoplasmic granule. Note=Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors. |
| Tissue Specificity | Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes. {ECO:0000269|PubMed:10806482, ECO:0000269|PubMed:11004490, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11342471, ECO:0000269|PubMed:11854040, ECO:0000269|PubMed:12176024, ECO:0000269|PubMed:15061151, ECO:0000269|PubMed:17482170, ECO:0000269|PubMed:18055825}. |
| Top Pathways | Rap1 signaling pathway, Cytokine-cytokine receptor interaction, Choline metabolism in cancer, PI3K-Akt signaling pathway, Prostate cancer |
Active human PDGF CC protein fragment - ab84066 from Abcam
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Human PDGFC full length protein - ab132727 from Abcam
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Human PDGFC peptide - ab108275 from Abcam
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Human PDGFC protein fragment - ab191760 from Abcam
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PDGF-CC Antibody Blocking Peptide - LS-E22561 from LifeSpan Bioscience
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PDGF-CC Antibody Blocking Peptide - LS-E22560 from LifeSpan Bioscience
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Human PDGF-CC Biologically Active Protein - NBP2-36587 from Novus Biologicals
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Human PDGF-CC Biologically Active Protein - NBP2-36501 from Novus Biologicals
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Recombinant Human PDGF-CC Protein - NBP2-36517 from Novus Biologicals
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Recombinant Human PDGF-C Protein - H00056034-Q01 from Novus Biologicals
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PDGF-C Recombinant Protein - H00056034-P01 from Novus Biologicals
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Recombinant Human PDGF-CC - 1687-CC-025 from R&D Systems
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Recombinant Human PDGF-CC, CF - 1687-CC-025/CF from R&D Systems
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VEGF-E (Orf Virus) protein - orb80646 from Biorbyt
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VEGF-E (Orf Virus) protein - orb176840 from Biorbyt
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Human PDGF-C protein (His Tag) - orb139456 from Biorbyt
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VEGFE protein (Orf virus) - 30R-AV011 from Fitzgerald
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Human PDGFC Protein - abx068585 from Abbexa
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PDGFC (PDGF-CC) - AR01009PU-N from Acris Antibodies
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PDGFC (PDGF-CC) - AR01009PU-S from Acris Antibodies
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PDGFC - H00056034-P01-10 from Acris Antibodies
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PDGFC - H00056034-P01-25 from Acris Antibodies
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PDGFC - H00056034-Q01-10 from Acris Antibodies
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PDGFC - H00056034-Q01-25 from Acris Antibodies
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PDGFC - P6130 from Acris Antibodies
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