| Gene Symbol | GRIA1 |
|---|---|
| Entrez Gene | 2890 |
| Alt Symbol | GLUH1, GLUR1, GLURA, GluA1, HBGR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamate receptor, ionotropic, AMPA 1 |
| Other Description | AMPA 1|AMPA-selective glutamate receptor 1|gluR-1|gluR-A|gluR-K1|glutamate receptor 1 |
| Swissprots | D3DQI4 Q2NKM6 E7ESV8 B7Z9G9 P42261 B7Z2W8 B7Z3F6 B7Z2S0 |
| Accessions | EAW61649 EAW61650 EAW61651 P42261 AB209094 BAD92331 AK289565 BAF82254 AK294011 BAH11647 AK294773 BAH11879 AK295039 BAH11956 AK295184 BAH12004 AK295827 BAH12192 AK310189 AK315934 BAH14305 AL120214 BC111734 AAI11735 DC335107 FJ947077 ACR45954 FJ947078 ACR45955 M64752 AAA58613 M81886 AAA58395 X58633 CAA41491 Z70220 XM_011537635 XP_011535937 XR_427776 NM_000827 NP_000818 NM_001114183 NP_001107655 NM_001258019 NP_001244948 NM_001258020 NP_001244949 NM_001258021 NP_001244950 NM_001258022 NP_001244951 NM_001258023 NP_001244952 NR_047578 |
| Function | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}. |
| Tissue Specificity | Widely expressed in brain. |
| Top Pathways | cAMP signaling pathway, Circadian entrainment, Retrograde endocannabinoid signaling, Nicotine addiction, Amphetamine addiction |