GRIA1

Gene Symbol GRIA1
Entrez Gene 2890
Alt Symbol GLUH1, GLUR1, GLURA, GluA1, HBGR1
Species Human
Gene Type protein-coding
Description glutamate receptor, ionotropic, AMPA 1
Other Description AMPA 1|AMPA-selective glutamate receptor 1|gluR-1|gluR-A|gluR-K1|glutamate receptor 1
Swissprots D3DQI4 Q2NKM6 E7ESV8 B7Z9G9 P42261 B7Z2W8 B7Z3F6 B7Z2S0
Accessions EAW61649 EAW61650 EAW61651 P42261 AB209094 BAD92331 AK289565 BAF82254 AK294011 BAH11647 AK294773 BAH11879 AK295039 BAH11956 AK295184 BAH12004 AK295827 BAH12192 AK310189 AK315934 BAH14305 AL120214 BC111734 AAI11735 DC335107 FJ947077 ACR45954 FJ947078 ACR45955 M64752 AAA58613 M81886 AAA58395 X58633 CAA41491 Z70220 XM_011537635 XP_011535937 XR_427776 NM_000827 NP_000818 NM_001114183 NP_001107655 NM_001258019 NP_001244948 NM_001258020 NP_001244949 NM_001258021 NP_001244950 NM_001258022 NP_001244951 NM_001258023 NP_001244952 NR_047578
Function Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.
Tissue Specificity Widely expressed in brain.
Top Pathways cAMP signaling pathway, Circadian entrainment, Retrograde endocannabinoid signaling, Nicotine addiction, Amphetamine addiction

Phospho-AMPA Receptor (GluR 1) (Ser845) (D10G5) Rabbit mAb - 8084 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10G5
Western blot analysis of extracts from mouse brain and rat brain using Phospho-AMPA Receptor (GluR 1) (Ser845) (D10G5) Rabbit mAb. The phospho-specificity of the antibody was verified by blocking with a phospho or nonphosphopeptide.

AMPA Receptor (GluR 1) (D4N9V) Rabbit mAb - 13185 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4N9V
Western blot analysis of extracts from mouse brain, rat brain, and rat prefrontal cortex tissues using AMPA Receptor (GluR 1) (D4N9V) Rabbit mAb.

AMPA Receptor (GluR 1) Antibody - 8850 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

GluR-1 (E-6) - sc-13152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GluR-1 (E-6): sc-13152. Western blot analysis of GluR-1 expression in mouse brain tissue extract.

GluR-1 (H-301) - sc-28799 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

GluR-1 (G-12) - sc-55509 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GluR-1 (G-12): sc-55509. Western blot analysis of GluR-1 expression in mouse brain (A), rat brain (B) and rat cerebellum (C) tissue extracts.

GluR-1 (P-20) - sc-26472 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GluR-1 (C-19) - sc-7609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GluR-1 (C-19): SC-7609. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human brain tumor showing membrane staining.

p-GluR-1 (Ser 831) - sc-16313 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-GluR-1 (Ser 831)-R: sc-16313-R. Western blot analysis of GluR-1 phosphorylation in untreated (A) and lambda protein phosphatase treated (B) mouse brain tissue extracts.

p-GluR-1 (Ser 845) - sc-16314 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-GluR-1 (Ser 845)-R: sc-16314-R. Western blot analysis of GluR-1 phosphorylation in untreated (A) and lambda protein phosphatase (sc-200312A) treated (B) mouse brain tissue extracts.

p-GluR-1 (Ser 863) - sc-12624 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-GluR-1 (Ser 849) - sc-101688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of phosphorylated GluR-1 expression in mouse brain tissue extract. Blots were probed with p-GluR-1 (Ser 849): sc-101688 preincubated with cognate phosphorylated peptide (A) and p-GluR-1 (Ser 849): sc-101688 (B).

p-GluR-1 (Ser 845) - sc-135699 from Santa Cruz Biotechnology

Prices $279.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
p-GluR-1 (Ser 845): sc-135699. Western blot analysis of GluR-1 phosphorylation in untreated (A) and lambda protein phosphatase-treated (B) rat hippocampal tissue extracts.

p-GluR-1 (Ser 831) - sc-135698 from Santa Cruz Biotechnology

Prices $279.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
p-GluR-1 (Ser 831): sc-135698. Western blot analysis of GluR-1 phosphorylation in untreated (A) and lambda protein phosphatase-treated (B) rat hippocampal tissue extracts.

Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S831) antibody [EPR1887] - ab109464 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1887
All lanes : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S831) antibody [EPR1887] (ab109464) at 1/1000 dilutionLane 1 : Rat brain lysates, untreated Lane 2 : Rat brain lysates treated with Lambda PhosphataseLysates/proteins at 10 µg per lane.SecondaryHRP-labelled goat anti-rabbit at 1/2000 dilution

Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S836) antibody - ab119397 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S836) antibody (ab119397) at 1/500 dilutionLane 1 : ControlLane 2 : Mouse Brain extract

Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S836) antibody - ab194909 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S836) antibody (ab194909) at 1/500 dilution + Mouse brain extract

Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S845) antibody - ab3901 from Abcam

Prices $376.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal

Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S845) antibody [EPR2148] - ab76321 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2148
All lanes : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S845) antibody [EPR2148] (ab76321) at 1/20000 dilutionLane 1 : Rat brain lysate, untreatedLane 2 : Rat brain lysate treated with Lambda PhosphataseLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/1000 dilution

Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S849) antibody - ab194774 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S849) antibody (ab194774) at 1/500 dilution + Rat brain tissue extract

Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S849) antibody - ab51063 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Human brain tissue labelled with ab51063 at 1/50 dilution.

Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S863) antibody - ab195696 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S863) antibody (ab195696) at 1/500 dilutionLane 1 : Whole lysate of HeLa cells treated with PMA with antigen-specific peptideLane 2 : Whole lysate of HeLa cells treated with PMALysates/proteins at 12.5 µg per lane.

Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S863) antibody - ab51066 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Human brain tissue labelled with ab51066 at 1/50 dilution.

Anti-Glutamate Receptor 1 (AMPA subtype) (phospho T840) antibody - ab12108 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho T840) antibody (ab12108) at 0.3 µg/mlLane 2 : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho T840) antibody (ab12108) at 1 µg/mlLanes 3 - 5 : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho T840) antibody (ab12108) at 3 µg/mlLane 1 : mouse brain extractLane 2 : mouse brain extractLane 3 : mouse brain extractLane 4 : mouse brain extract with Mouse Glutamate Receptor 1 (AMPA subtype) (phospho T840) peptide (ab12399) at 2 µg/mlLane 5 : mouse brain extract with Mouse Glutamate Receptor 1 (AMPA subtype) (unmodified ) peptide (ab12434) at 2 µg/mlPerformed under reducing conditions.

Anti-Glutamate Receptor 1 (AMPA subtype) antibody - ab31232 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistical detection of Glutamate Receptor 1 (AMPA subtype)  with ab31232 on formaldehyde-fixed paraffin-embedded rat cerebellum sections. Antigen retrieval step: heat mediated  in citric acid pH6. Blocking step: 1% BSA  for 10 mins @ rt°C.  Primary antibody was incubated at 1/200 for 2 hours @ room temp. Secondary antibody: anti-rabbit IgGs conjugated to biotin (1/200). The composite image shows localisation of this protein apparently exclusive to the molecular layer of the cerebellum upper image (low power). In the lower image (higher power), the molecular layer positivity appears to be compartmentalised/restricted.See Abreview
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