Gene Symbol | MTMR6 |
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Entrez Gene | 9107 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | myotubularin related protein 6 |
Other Description | myotubularin-related protein 6 |
Swissprots | B2RBB5 B3KSB4 Q9Y217 Q96P80 Q86TB7 Q5JRG6 Q86YH4 |
Accessions | EAX08367 Q9Y217 AF072928 AAC78841 AF406619 AAL01037 AK025507 AK093237 AK094082 AK314587 BAG37162 AL044815 AL832017 CAD89918 AM392681 CAL37559 AM392837 CAL37715 BC031834 AAH31834 BC035436 BC040012 AAH40012 BU177677 EF491793 U47635 AAB18856 XM_011535306 XP_011533608 XM_011535307 XP_011533609 XM_011535308 XP_011533610 NM_004685 NP_004676 |
Function | Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells. {ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315}. |
Subcellular Location | Nucleus envelope {ECO:0000269|PubMed:16787938}. |
Tissue Specificity | Expressed in CD4+ T-cells. {ECO:0000269|PubMed:16847315}. |
MTMR6 CRISPR/Cas9 KO Plasmid (h) - sc-406499 from Santa Cruz Biotechnology
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MTMR6 HDR Plasmid (h) - sc-406499-HDR from Santa Cruz Biotechnology
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MTMR6 Double Nickase Plasmid (h) - sc-406499-NIC from Santa Cruz Biotechnology
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MTMR6 Double Nickase Plasmid (h2) - sc-406499-NIC-2 from Santa Cruz Biotechnology
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MTMR6 CRISPR Activation Plasmid (h) - sc-406499-ACT from Santa Cruz Biotechnology
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MTMR6 CRISPR Activation Plasmid (h2) - sc-406499-ACT-2 from Santa Cruz Biotechnology
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MTMR6 Lentiviral Activation Particles (h) - sc-406499-LAC from Santa Cruz Biotechnology
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MTMR6 Lentiviral Activation Particles (h2) - sc-406499-LAC-2 from Santa Cruz Biotechnology
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MTMR6 siRNA (h) - sc-61093 from Santa Cruz Biotechnology
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MTMR6 shRNA Plasmid (h) - sc-61093-SH from Santa Cruz Biotechnology
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MTMR6 shRNA (h) Lentiviral Particles - sc-61093-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU069631 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0338 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0337 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0339 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14721 from Sigma-Aldrich
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MTMR6 siRNA (Human) - CRH6017 from Cohesion Biosciences
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MTMR6 RNAi - H00009107-R01 from Novus Biologicals
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shRNA set against Human MTMR6 (NM_004685.3) - SHH346528 from Creative biogene
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MTMR6 shRNA Plasmid (Human) - CHH6017 from Cohesion Biosciences
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MTMR6 miRNA 3'UTR clone - MiUTR1H-06518 from Creative biogene
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