SRRT

Gene Symbol SRRT
Entrez Gene 51593
Alt Symbol ARS2, ASR2, serrate
Species Human
Gene Type protein-coding
Description serrate, RNA effector molecule
Other Description arsenate resistance protein 2|arsenate resistance protein ARS2|arsenite resistance protein|arsenite-resistance protein 2|serrate RNA effector molecule homolog
Swissprots Q32MI4 A6NK22 Q6NT74 Q9BWP6 A4D2E6 Q9BXP4 B4DZA6 A4D2E5 Q9Y4S4 Q9BXP5 Q8TDQ5 B4DJL4 O95808
Accessions AAG24951 AAK21005 AAK21006 EAL23815 EAL23816 EAW76465 EAW76466 EAW76467 Q9BXP5 AF082871 AAD17774 AF112994 AAP97227 AF248955 AAM00189 AK296131 BAG58876 AK302820 BAG64018 AK311728 AL096723 CAB46374 AW770857 BC000082 AAH00082 BC069249 AAH69249 BC109116 BC109117 AAI09118 BE247268 BE297447 BF515651 BG477711 BG685713 BQ059529 DA611314 XM_005250405 XP_005250462 XM_005250406 XP_005250463 XM_005250407 XP_005250464 XM_005250408 XP_005250465 XM_006716023 XP_006716086 XM_011516291 XP_011514593 NM_182800 NM_001128852 NP_001122324 NM_001128853 NP_001122325 NM_001128854 NP_001122326 NM_015908 NP_056992
Function Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:18086880}.

ARS2 (H-300) - sc-135083 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ARS2 (H-300): sc-135083. Western blot analysis of ARS2 expression in mouse lymph node tissue extract (A) and T24 whole cell lysate (B).

ARS2 (C-14) - sc-162539 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ARS2 (C-14): sc-162539. Western blot analysis of ARS2 expression in non-transfected 293T: sc-117752 (A), mouse ARS2 transfected 293T: sc-118573 (B) and U-251-MG (C) whole cell lysates.

ARS2 (K-15) - sc-162540 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ARS2 antibody - ab88392 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-ARS2 antibody (ab88392) at 1 µg/ml + human pancreas tissue lysate at 50 µg

Anti-ARS2 antibody - ab130558 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ARS2 antibody (ab130558) at 1/100 dilution + 293 cell lysate at 35 µg

Anti-ARS2 antibody - ab55822 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SRRT / ARS2 Antibody (C-Terminus) - LS-C46918 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SRRT / ARS2 Antibody (aa53-81, AP) - LS-C270394 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRRT / ARS2 Antibody (aa53-81, APC) - LS-C270395 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRRT / ARS2 Antibody (aa53-81, Biotin) - LS-C270396 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRRT / ARS2 Antibody (aa53-81, FITC) - LS-C270397 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRRT / ARS2 Antibody (aa53-81, Azide-free, HRP) - LS-C270398 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRRT / ARS2 Antibody (aa53-81) - LS-C325391 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRRT / ARS2 Antibody (aa53-81, PE) - LS-C270399 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRRT / ARS2 Antibody (aa53-81) - LS-C157094 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SRRT Antibody western blot of 293 cell line lysates (35 ug/lane). The SRRT antibody detected the SRRT protein (arrow).

ARS2 Antibody - H00051593-B02P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: ARS2 Antibody [H00051593-B02P] - Analysis of ARS2 expression in human pancreas.

ARS2 Antibody - NBP2-13382 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ARS2 Antibody [NBP2-13382] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

ARS2 Antibody - NBP2-15473 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ARS2 Antibody [NBP2-15473] - Sample (30 ug of whole cell lysate) A: Jurkat 7. 5% SDS PAGE gel, diluted at 1:10000.

ARS2 Polyclonal Antibody - bs-7970R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-SRRT (N-TERM) antibody produced in rabbit - SAB1304594 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SRRT (N-term): <B>Cat. No. SAB1304594</B>: SRRT Antibody (N-term) western blot analysis in HEK_293 cell line lysates (35 μg/lane).

Anti-ARS2 antibody produced in mouse - SAB1400566 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-ARS2, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400566</B>: Antibody concentration: 1.0 ~ 5.0 μg/mL. Specific band of ~100.7 kDa using human pancreas lysate.

Anti-SRRT antibody produced in rabbit - HPA042858 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SRRT:<B>Cat. No. HPA042858</B>: Immunohistochemical staining of human colon shows strong nuclear positivity in glandular cells.

Anti-SRRT antibody produced in rabbit - SAB2700629 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SRRT: <B>Cat. No. SAB2700629</B>: Immunohistochemical analysis of paraffin-embedded Breast carcinoma, using ARS2 antibody at 1:500 dilution.

SRRT-Antibody-N-term - AP17241a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
SRRT Antibody (N-term) (Cat. #AP17241a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SRRT antibody detected the SRRT protein (arrow).

Goat-Anti-SRRT--ARS2-Antibody - AF4136a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF4136a (0.1 µg/ml) staining of Daudi (A) and Mouse Spleen (B) lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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