DAXX

Gene Symbol	DAXX
Entrez Gene	1616
Alt Symbol	BING2, DAP6, EAP1
Species	Human
Gene Type	protein-coding
Description	death-domain associated protein
Other Description	CENP-C binding protein|ETS1-associated protein 1|Fas-binding protein|death domain-associated protein 6|death-associated protein 6|fas death domain-associated protein
Swissprots	Q5STK9 F5ANJ6 O14747 Q9BWI3 Q9UER7 O15141 O15208 F5ANJ7 B4E1I3 F5H082
Accessions	CAB09986 CAB09989 EAX03722 EAX03723 EAX03724 Q9UER7 AA533586 AB209493 BAD92730 AF006041 AAB63043 AF015956 AAB66585 AF039136 AAB92671 AF050179 AAC39853 AF097742 AAC72843 AK223404 BAD97124 AK292187 BAF84876 AK303767 BAG64733 AK303854 BAG64795 AK309612 AK313034 BAG35867 BC000220 AAH00220 BC073776 BC109073 AAI09074 BC109074 AAI09075 BM997178 CR457085 CAG33366 DC345308 DC359186 EU446949 ABZ92478 HQ436528 AEC33235 HQ436529 AEC33236 XM_005248860 XP_005248917 XM_005275218 XP_005275275 XM_005275354 XP_005275411 NM_001141969 NP_001135441 NM_001141970 NP_001135442 NM_001254717 NP_001241646 NM_001350 NP_001341
Function	Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activatiopn of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination
Subcellular Location	Isoform gamma: Nucleus {ECO:0000269|PubMed:21482821}. Note=Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. {ECO:0000269|PubMed:21482821}.
Tissue Specificity	Ubiquitous.
Top Pathways	Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Daxx peptide - ab7879 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human Daxx full length protein - ab131785 from Abcam Category Protein Source Wheat germ Species Human

Human Daxx protein fragment - ab152329 from Abcam Category Protein Source Wheat germ Species Human

DAXX Blocking Peptide - LS-E7411 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAXX Antibody Blocking Peptide - LS-E7269 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAXX Antibody Blocking Peptide - LS-E29860 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Daxx Protein - H00001616-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Daxx Protein - H00001616-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Daxx Blocking Peptide - NBP1-77011PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Daxx Peptide - P1664 from Novus Biologicals Category Peptide Species Human

Daxx Peptide - P1308 from Novus Biologicals Category Peptide Species Human

Phospho-DAXXS213-Antibody-Blocking-peptide - BP3082a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-DAXXS671-Antibody-Blocking-peptide - BP3532a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

DAXX-Antibody-S495-Blocking-Peptide - BP7773a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Daxx peptide - GTX27879 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Human DAXX protein - orb245070 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

DAXX Blocking Peptide - abx062526 from Abbexa Category Peptide Species Human, Monkey

DAXX - H00001616-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DAXX - H00001616-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DAXX - H00001616-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DAXX - H00001616-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DAXX Control Peptide - AP30275CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Recombinant Human Daxx, HEK293 Lysate - 230-10050-100 from RayBiotech Category Protein Prices $154.00 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Recombinant Human Daxx, HEK293 Transfected Cell Culture Supernatant - 230-20028-200 from RayBiotech Category Protein Prices $113.00 Sizes 200 µl Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Daxx Peptide - 1163P from ProSci Category Peptide Species Human

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