Gene Symbol | ATPIF1 |
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Entrez Gene | 93974 |
Alt Symbol | ATPI, ATPIP, IP |
Species | Human |
Gene Type | protein-coding |
Description | ATPase inhibitory factor 1 |
Other Description | ATP synthase inhibitor protein|ATPase inhibitor protein|ATPase inhibitor, mitochondrial|IF(1)|IF1|inhibitor of F(1)F(o)-ATPase |
Swissprots | Q6IAQ7 Q9UII2 Q9BSL9 Q5JXL8 |
Accessions | AAF97495 EAX07704 EAX07705 EAX07706 Q9UII2 AB029042 BAA88422 AF114836 AAP97235 AK000934 AK316600 BAG38187 AL050386 CAI46227 AL583540 BC004955 AAH04955 BC009677 AAH09677 BC017562 BG036978 BG337531 BG714388 BP271519 BT009849 AAP88851 CR457097 CAG33378 DB030607 EU832478 ACE87650 EU832558 ACE86960 NM_016311 NP_057395 NM_178190 NP_835497 NM_178191 NP_835498 |
Function | Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:12110673}. |
ATPIF1 (D6P1Q) XP ® Rabbit mAb - 13268 from Cell Signaling Technology
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ATPIF1 Antibody - 8528 from Cell Signaling Technology
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ATPIF1 (A-3) - sc-271614 from Santa Cruz Biotechnology
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ATPIF1 (M-78) - sc-134962 from Santa Cruz Biotechnology
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ATPIF1 (FL-106) - sc-134961 from Santa Cruz Biotechnology
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ATPIF1 (G-13) - sc-162557 from Santa Cruz Biotechnology
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ATPIF1 (S-12) - sc-162558 from Santa Cruz Biotechnology
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ATPIF1 (E-12) - sc-162556 from Santa Cruz Biotechnology
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Anti-ATPase Inhibitory Factor 1 antibody - ab197806 from Abcam
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Anti-ATPase Inhibitory Factor 1 antibody - ab57694 from Abcam
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Anti-ATPase Inhibitory Factor 1 antibody - Aminoterminal end - ab139125 from Abcam
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Anti-ATPIF1 / ATPI Antibody (aa1-107, Azide-free) - LS-C126913 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody (aa8-35, AP) - LS-C252078 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody (aa8-35, APC) - LS-C252079 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody (aa8-35, Biotin) - LS-C252080 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody (aa8-35, FITC) - LS-C252081 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody (aa38-87) - LS-C81241 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody (aa8-35, Azide-free, HRP) - LS-C252082 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody (aa8-35, PE) - LS-C252084 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody (aa8-35) - LS-C159142 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody - LS-C306457 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody - LS-C306459 from LifeSpan Bioscience
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Anti-ATPIF1 / ATPI Antibody (aa8-35) - LS-C319717 from LifeSpan Bioscience
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ATPase Inhibitory Factor 1 Antibody - NBP1-90069 from Novus Biologicals
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ATPase Inhibitory Factor 1 Antibody (3E2) - H00093974-M01 from Novus Biologicals
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