Gene Symbol | ATPIF1 |
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Entrez Gene | 93974 |
Alt Symbol | ATPI, ATPIP, IP |
Species | Human |
Gene Type | protein-coding |
Description | ATPase inhibitory factor 1 |
Other Description | ATP synthase inhibitor protein|ATPase inhibitor protein|ATPase inhibitor, mitochondrial|IF(1)|IF1|inhibitor of F(1)F(o)-ATPase |
Swissprots | Q6IAQ7 Q9UII2 Q9BSL9 Q5JXL8 |
Accessions | AAF97495 EAX07704 EAX07705 EAX07706 Q9UII2 AB029042 BAA88422 AF114836 AAP97235 AK000934 AK316600 BAG38187 AL050386 CAI46227 AL583540 BC004955 AAH04955 BC009677 AAH09677 BC017562 BG036978 BG337531 BG714388 BP271519 BT009849 AAP88851 CR457097 CAG33378 DB030607 EU832478 ACE87650 EU832558 ACE86960 NM_016311 NP_057395 NM_178190 NP_835497 NM_178191 NP_835498 |
Function | Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:12110673}. |
ATPIF1 CRISPR/Cas9 KO Plasmid (h) - sc-403038 from Santa Cruz Biotechnology
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ATPIF1 HDR Plasmid (h) - sc-403038-HDR from Santa Cruz Biotechnology
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ATPIF1 Double Nickase Plasmid (h) - sc-403038-NIC from Santa Cruz Biotechnology
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ATPIF1 Double Nickase Plasmid (h2) - sc-403038-NIC-2 from Santa Cruz Biotechnology
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ATPIF1 CRISPR Activation Plasmid (h) - sc-403038-ACT from Santa Cruz Biotechnology
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ATPIF1 CRISPR Activation Plasmid (h2) - sc-403038-ACT-2 from Santa Cruz Biotechnology
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ATPIF1 Lentiviral Activation Particles (h) - sc-403038-LAC from Santa Cruz Biotechnology
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ATPIF1 Lentiviral Activation Particles (h2) - sc-403038-LAC-2 from Santa Cruz Biotechnology
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ATPIF1 siRNA (h) - sc-78711 from Santa Cruz Biotechnology
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ATPIF1 shRNA Plasmid (h) - sc-78711-SH from Santa Cruz Biotechnology
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ATPIF1 shRNA (h) Lentiviral Particles - sc-78711-V from Santa Cruz Biotechnology
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ATPase Inhibitory Factor 1 RNAi - H00093974-R03 from Novus Biologicals
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ATPase Inhibitory Factor 1 RNAi - H00093974-R01 from Novus Biologicals
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MISSION® esiRNA - EHU141171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3752 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3752 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09980 from Sigma-Aldrich
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ATPIF1 siRNA (Human) - CRJ4230 from Cohesion Biosciences
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ATPase Inhibitory Factor 1 RNAi - H00093974-R02 from Novus Biologicals
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ATPIF1 - MBS827890 from MyBioSource
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shRNA set against Human ATPI (NM_178191.2) - SHH243438 from Creative biogene
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Human ATPIF1 siRNA - orb274731 from Biorbyt
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ATPIF1 shRNA Plasmid (Human) - CHJ4230 from Cohesion Biosciences
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ATPIF1 miRNA 3'UTR clone - MiUTR3H-13699 from Creative biogene
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ATPIF1 miRNA 3'UTR clone - MiUTR3H-13700 from Creative biogene
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