| Gene Symbol | RAB17 |
|---|---|
| Entrez Gene | 64284 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAB17, member RAS oncogene family |
| Other Description | ras-related protein Rab-17 |
| Swissprots | Q9H0T7 Q6IA73 Q9H9U9 Q53QV6 Q9BVU1 Q6PJZ0 |
| Accessions | AAY24047 EAW71118 EAW71119 EAW71120 Q9H0T7 AK022600 BAB14121 AK225423 AL136645 CAB66580 AM392800 CAL37678 BC000929 AAH00929 BC007907 AAH07907 BC009827 AAH09827 BC023661 BC050426 AAH50426 BP313619 BX647412 CR457282 CAG33563 CR533454 CAG38485 XM_006712687 XP_006712750 XM_006712688 XP_006712751 XM_006712689 XP_006712752 NM_022449 NP_071894 NR_033308 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post- endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role |
| Subcellular Location | Recycling endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in melanocytes (at protein level). {ECO:0000269|PubMed:21291502}. |