Gene Symbol | ARHGAP27 |
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Entrez Gene | 201176 |
Alt Symbol | CAMGAP1, PP905, SH3D20, SH3P20 |
Species | Human |
Gene Type | protein-coding |
Description | Rho GTPase activating protein 27 |
Other Description | CIN85-associated multi-domain-containing Rho GTPase-activating protein 1|SH3 domain containing 20|SH3 domain-containing protein 20|rho GTPase-activating protein 27|rho-type GTPase-activating protein 27 |
Swissprots | Q8WY58 C9JTF3 Q494U0 A8K3N5 Q6NWZ8 Q6ZUM4 A4FU35 |
Accessions | EAW51527 EAW51528 Q6ZUM4 AF258593 AAG23796 AK092891 AK125535 BAC86196 AK290650 BAF83339 AK300880 BAH13366 BC029634 AAH29634 BC067345 AAH67345 BC101388 AAI01389 BC101389 AAI01390 BC101390 AAI01391 BC101391 AAI01392 BX386761 CD675139 XM_005257128 XP_005257185 XM_005275642 XP_005275699 XM_006721745 XP_006721808 XM_006721747 XP_006721810 XM_006721750 XP_006721813 XM_006725259 XP_006725322 XM_006725261 XP_006725324 XM_006725608 XP_006725671 XM_006725610 XP_006725673 XM_006725613 XP_006725676 XM_006725615 XP_006725678 XM_011524468 XP_011522770 XM_011524469 XP_011522771 XM_011524470 XP_011522772 XM_011524471 XP_011522773 XM_011524472 XP_011522774 XM_011524473 XP_011522775 XM_011524474 XP_011522776 XM_011546333 XP_011544635 XM_011546334 XP_011544636 XM_011546335 XP_011544637 XM_011546336 XP_011544638 XM_011546337 XP_011544639 XM_011546338 XP_011544640 XM_011546339 XP_011544641 XM_011547464 XP_011545766 XM_011547465 XP_011545767 XM_011547466 XP_011545768 XM_011547467 XP_011545769 XM_011547468 XP_011545770 XM_011547469 XP_011545771 XM_011547470 XP_011545772 XR_429873 XR_429875 XR_429876 XR_430745 XR_430747 XR_430898 XR_430900 XR_430901 XR_934416 XR_934417 XR_934418 XR_951533 XR_952465 XR_952466 XR_952467 NM_001159330 NM_001282290 NP_001269219 NM_174919 NP_777579 NM_199282 NP_954976 |
Function | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer and lung cancer. {ECO:0000269|PubMed:15492870}. |
ARHGAP27 CRISPR/Cas9 KO Plasmid (h) - sc-415008 from Santa Cruz Biotechnology
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ARHGAP27 HDR Plasmid (h) - sc-415008-HDR from Santa Cruz Biotechnology
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ARHGAP27 Double Nickase Plasmid (h) - sc-415008-NIC from Santa Cruz Biotechnology
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ARHGAP27 Double Nickase Plasmid (h2) - sc-415008-NIC-2 from Santa Cruz Biotechnology
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ARHGAP27 CRISPR Activation Plasmid (h) - sc-415008-ACT from Santa Cruz Biotechnology
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ARHGAP27 CRISPR Activation Plasmid (h2) - sc-415008-ACT-2 from Santa Cruz Biotechnology
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ARHGAP27 Lentiviral Activation Particles (h) - sc-415008-LAC from Santa Cruz Biotechnology
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ARHGAP27 Lentiviral Activation Particles (h2) - sc-415008-LAC-2 from Santa Cruz Biotechnology
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ARHGAP27 siRNA (h) - sc-93628 from Santa Cruz Biotechnology
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ARHGAP27 shRNA Plasmid (h) - sc-93628-SH from Santa Cruz Biotechnology
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ARHGAP27 shRNA (h) Lentiviral Particles - sc-93628-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU118651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3421 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09803 from Sigma-Aldrich
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ARHGAP27 siRNA (Human) - CRJ6280 from Cohesion Biosciences
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ARHGAP27 - MBS8210895 from MyBioSource
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shRNA set against Human ARHGAP27 (NM_199282.2) - SHH239454 from Creative biogene
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ARHGAP27 shRNA Plasmid (Human) - CHJ6280 from Cohesion Biosciences
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ARHGAP27 miRNA 3'UTR clone - MiUTR3H-11336 from Creative biogene
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ARHGAP27 miRNA 3'UTR clone - MiUTR3H-11337 from Creative biogene
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