Gene Symbol | PLOD1 |
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Entrez Gene | 5351 |
Alt Symbol | EDS6, LH, LH1, LLH, PLOD |
Species | Human |
Gene Type | protein-coding |
Description | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 |
Other Description | lysine hydroxylase|lysyl hydroxlase 1|procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1|procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 |
Swissprots | Q9H132 Q02809 B4DR87 Q96AV9 |
Accessions | AAD52693 AAM12752 EAW71724 EAW71725 Q02809 AK124035 AK294688 BAG57849 AK295254 BAG58243 AK299150 BAG61199 AK312243 BAG35176 AK316285 BAH14656 AU139472 BC016657 AAH16657 BQ447373 DC334246 M98252 XM_011541593 XP_011539895 XM_011541594 XP_011539896 NM_000302 NP_000293 |
Function | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. |
Subcellular Location | Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. |
Top Pathways | Lysine degradation |
LLH1 CRISPR/Cas9 KO Plasmid (h) - sc-404079 from Santa Cruz Biotechnology
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LLH1 HDR Plasmid (h) - sc-404079-HDR from Santa Cruz Biotechnology
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LLH1 Double Nickase Plasmid (h) - sc-404079-NIC from Santa Cruz Biotechnology
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LLH1 Double Nickase Plasmid (h2) - sc-404079-NIC-2 from Santa Cruz Biotechnology
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LLH1 CRISPR Activation Plasmid (h) - sc-404079-ACT from Santa Cruz Biotechnology
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LLH1 CRISPR Activation Plasmid (h2) - sc-404079-ACT-2 from Santa Cruz Biotechnology
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LLH1 Lentiviral Activation Particles (h) - sc-404079-LAC from Santa Cruz Biotechnology
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LLH1 Lentiviral Activation Particles (h2) - sc-404079-LAC-2 from Santa Cruz Biotechnology
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LLH1 siRNA (h) - sc-60948 from Santa Cruz Biotechnology
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LLH1 shRNA Plasmid (h) - sc-60948-SH from Santa Cruz Biotechnology
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LLH1 shRNA (h) Lentiviral Particles - sc-60948-V from Santa Cruz Biotechnology
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PLOD1 RNAi - H00005351-R01 from Novus Biologicals
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MISSION® esiRNA - EHU009851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16993 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16993 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06237 from Sigma-Aldrich
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PLOD1 siRNA (Human) - CRH3590 from Cohesion Biosciences
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shRNA set against Human PLOD1 (NM_000302.3) - SHH377976 from Creative biogene
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PLOD1 shRNA Plasmid (Human) - CHH3590 from Cohesion Biosciences
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PLOD1 miRNA 3'UTR clone - MiUTR3H-01362 from Creative biogene
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