CRY2

Gene Symbol CRY2
Entrez Gene 1408
Alt Symbol HCRY2, PHLL2
Species Human
Gene Type protein-coding
Description cryptochrome circadian clock 2
Other Description cryptochrome 2 (photolyase-like)|cryptochrome-2|growth-inhibiting protein 37
Swissprots B4DH32 O75148 B4DZD6 Q49AN0 Q8IV71
Accessions ABM64210 EAW68029 EAW68030 Q49AN0 AB014558 BAA31633 AI375851 AK001194 AK291260 BAF83949 AK294904 BAG57993 AK295627 BAG58504 AK302865 BAG64048 BC035161 AAH35161 BC041814 AAH41814 BG260501 DC306642 DC330290 EU219622 ACA14134 JF432374 ADZ15591 NM_001127457 NP_001120929 NM_021117 NP_066940
Function Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9801304}. Nucleus {ECO:0000269|PubMed:9801304}. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.
Tissue Specificity Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:8909283, ECO:0000269|PubMed:9801304}.
Top Pathways Circadian rhythm

CRY2 (A-20) - sc-5954 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CRY2 (A-20): sc-5954. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

CRY2 (H-73) - sc-33178 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CRY2 (H-73): sc-33178. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

CRY2 (P-21) - sc-130731 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CRY2 (P-21): sc-130731. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic localization.

Anti-CRY2 antibody - ab38872 from Abcam

Prices $390.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CRY2 antibody (ab38872) at 1/100 dilution + Mouse liver tissue lysate

Anti-CRY2 antibody - ab155255 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CRY2 antibody - ab93802 from Abcam

Prices $376.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CRY2 antibody (ab93802) at 0.04 µg/mlLane 1 : whole HeLa cell lysate at 50 µgLane 2 : whole HeLa cell lysate at 15 µgLane 3 : whole HeLa cell lysate at 5 µgLane 4 : whole 293T cell lysate at 50 µg

Anti-CRY2 antibody - ab167387 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CRY2 antibody (ab167387) at 1 µg/mlLane 1 : CRY2 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-CRY2 antibody [1H5] - ab119053 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H5
All lanes : Anti-CRY2 antibody [1H5] (ab119053) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY ControlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY CRY2Lysates/proteins at 5 µg per lane.

Anti-CRY2 Antibody (C-Terminus) - LS-C6228 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRY2 Antibody (C-Terminus) - LS-C6229 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRY2 Antibody (C-Terminus, APC) - LS-C206557 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRY2 Antibody (C-Terminus, Biotin) - LS-C206558 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRY2 Antibody (C-Terminus, AP) - LS-C206556 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRY2 Antibody (C-Terminus, FITC) - LS-C206559 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRY2 Antibody (C-Terminus, PE) - LS-C206560 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRY2 Antibody (aa543-593) - LS-C289346 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRY2 Antibody (C-Terminus, Azide-free, HRP) - LS-C207971 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRY2 Antibody - LS-C307102 from LifeSpan Bioscience

Host Mouse
Clonality Polyclonal

Anti-CRY2 Antibody (C-Terminus, Azide-free) - LS-C327131 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRY2 Antibody (aa179-228) - LS-C116485 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CRY2 antibody LS-C116485 Western blot of U937 cell lysate.

Anti-CRY2 Antibody (aa128-156) - LS-C167063 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CRY2 Antibody (N-term) Western blot analysis in HL-60 cell line lysates (35 ug/lane). This demonstrates the CRY2 antibody detected the CRY2 protein (arrow).

Anti-CRY2 Antibody - LS-C346134 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of HeLa cell using CRY2 antibody.

Anti-CRY2 Antibody (clone 3H4) - LS-C196969 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 3H4
Immunofluorescence of monoclonal antibody to CRY2 on HeLa cell . [antibody concentration 10 ug/ml]

Anti-CRY2 Antibody (aa579-593) IHC-plus™ - LS-B799 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CRY2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B799 concentration 10 ug/ml.

Anti-CRY2 Antibody (C-Terminus) - LS-C100383 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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