| Gene Symbol | CRY2 |
|---|---|
| Entrez Gene | 1408 |
| Alt Symbol | HCRY2, PHLL2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cryptochrome circadian clock 2 |
| Other Description | cryptochrome 2 (photolyase-like)|cryptochrome-2|growth-inhibiting protein 37 |
| Swissprots | B4DH32 O75148 B4DZD6 Q49AN0 Q8IV71 |
| Accessions | ABM64210 EAW68029 EAW68030 Q49AN0 AB014558 BAA31633 AI375851 AK001194 AK291260 BAF83949 AK294904 BAG57993 AK295627 BAG58504 AK302865 BAG64048 BC035161 AAH35161 BC041814 AAH41814 BG260501 DC306642 DC330290 EU219622 ACA14134 JF432374 ADZ15591 NM_001127457 NP_001120929 NM_021117 NP_066940 |
| Function | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9801304}. Nucleus {ECO:0000269|PubMed:9801304}. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL. |
| Tissue Specificity | Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:8909283, ECO:0000269|PubMed:9801304}. |
| Top Pathways | Circadian rhythm |