| Gene Symbol | CENPB |
|---|---|
| Entrez Gene | 1059 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | centromere protein B, 80kDa |
| Other Description | CENP-B|centromere autoantigen B|major centromere autoantigen B |
| Swissprots | P07199 Q96EI4 |
| Accessions | CAA38879 EAX10502 P07199 AF002713 AAB70165 AF002714 AAB70166 BC003649 BC012297 AAH12297 BC021577 BC033658 BC040446 BC053847 AAH53847 X05299 CAA28918 NM_001810 NP_001801 |
| Function | Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583, ECO:0000269|PubMed:18072184}. Chromosome, centromere {ECO:0000269|PubMed:18072184}. |