| Gene Symbol |
CENPB
|
| Entrez Gene |
1059
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centromere protein B, 80kDa
|
| Other Description |
CENP-B|centromere autoantigen B|major centromere autoantigen B
|
| Swissprots |
P07199 Q96EI4
|
| Accessions |
CAA38879 EAX10502 P07199 AF002713 AAB70165 AF002714 AAB70166 BC003649 BC012297 AAH12297 BC021577 BC033658 BC040446 BC053847 AAH53847 X05299 CAA28918 NM_001810 NP_001801
|
| Function |
Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583, ECO:0000269|PubMed:18072184}. Chromosome, centromere {ECO:0000269|PubMed:18072184}.
|
