Gene Symbol | CENPB |
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Entrez Gene | 1059 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | centromere protein B, 80kDa |
Other Description | CENP-B|centromere autoantigen B|major centromere autoantigen B |
Swissprots | P07199 Q96EI4 |
Accessions | CAA38879 EAX10502 P07199 AF002713 AAB70165 AF002714 AAB70166 BC003649 BC012297 AAH12297 BC021577 BC033658 BC040446 BC053847 AAH53847 X05299 CAA28918 NM_001810 NP_001801 |
Function | Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583, ECO:0000269|PubMed:18072184}. Chromosome, centromere {ECO:0000269|PubMed:18072184}. |
CENP-B CRISPR/Cas9 KO Plasmid (h) - sc-401356 from Santa Cruz Biotechnology
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CENP-B HDR Plasmid (h) - sc-401356-HDR from Santa Cruz Biotechnology
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CENP-B Double Nickase Plasmid (h) - sc-401356-NIC from Santa Cruz Biotechnology
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CENP-B Double Nickase Plasmid (h2) - sc-401356-NIC-2 from Santa Cruz Biotechnology
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CENP-B CRISPR Activation Plasmid (h) - sc-401356-ACT from Santa Cruz Biotechnology
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CENP-B CRISPR Activation Plasmid (h2) - sc-401356-ACT-2 from Santa Cruz Biotechnology
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CENP-B Lentiviral Activation Particles (h) - sc-401356-LAC from Santa Cruz Biotechnology
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CENP-B Lentiviral Activation Particles (h2) - sc-401356-LAC-2 from Santa Cruz Biotechnology
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CENP-B siRNA (h) - sc-37557 from Santa Cruz Biotechnology
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CENP-B shRNA Plasmid (h) - sc-37557-SH from Santa Cruz Biotechnology
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CENP-B shRNA (h) Lentiviral Particles - sc-37557-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN5938 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5938 from Sigma-Aldrich
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CENPB siRNA (Human) - CRH0764 from Cohesion Biosciences
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CENPB RNAi - H00001059-R01 from Novus Biologicals
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CENPB - MBS8232478 from MyBioSource
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shRNA set against Human CENPB (NM_001810.5) - SHH261589 from Creative biogene
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shRNA set against Human CENPB(NM_001810.5) - SHG167851 from Creative biogene
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CENP-B CRISPR/Cas9 KO Plasmid (h2) - sc-401356-KO-2 from Santa Cruz Biotechnology
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CENP-B HDR Plasmid (h2) - sc-401356-HDR-2 from Santa Cruz Biotechnology
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Human CENPB siRNA - orb261266 from Biorbyt
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CENPB shRNA Plasmid (Human) - CHH0764 from Cohesion Biosciences
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CENPB miRNA 3'UTR clone - MiUTR1H-02035 from Creative biogene
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