| Gene Symbol |
KALRN
|
| Entrez Gene |
8997
|
| Alt Symbol |
ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kalirin, RhoGEF kinase
|
| Other Description |
huntingtin-associated protein interacting protein (duo)|kalirin|serine/threonine kinase with Dbl- and pleckstrin homology domains|serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
|
| Swissprots |
Q6ZN45 Q8TBQ5 A8MSI4 Q9NSZ4 C9JQ37 Q9Y2A5 O60229
|
| Accessions |
EAW79410 EAW79414 EAW79415 EAW79416 EAW79417 EAW79418 EAW79419 EAW79420 EAW79421 EAW79422 EAW79423 O60229 AB011422 BAA76314 AI024603 AK022394 AK096580 AK123068 AK125979 BAC86373 AK126954 AK128223 AK131379 BAD18530 AK296657 BAG59254 AK311154 AK311581 AK314126 AL137629 CAB70850 BC026865 AAH26865 BC037924 BC058015 AAH58015 BC166705 AAI66705 BM930007 BQ345377 CB045666 DA756158 DB450617 HG496003 U94190 AAC15791 XM_006713810 XP_006713873 XM_006713811 XP_006713874 XM_006713812 XP_006713875 XM_006713813 XP_006713876 XM_006713814 XP_006713877 XM_006713815 XP_006713878 XM_006713817 XP_006713880 XM_011513279 XP_011511581 XM_011513280 XP_011511582 XM_011513281 XP_011511583 XM_011513282 XP_011511584 XM_011513283 XP_011511585 XM_011513284 XP_011511586 XM_011513285 XP_011511587 XM_011513286 XP_011511588 NM_001024660 NP_001019831 NM_003947 NP_003938 NM_007064 NP_008995 NR_028136
|
| Function |
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. {ECO:0000269|PubMed:10023074}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10023074}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10023074}. Note=Associated with the cytoskeleton.
|
| Tissue Specificity |
Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. {ECO:0000269|PubMed:10023074}.
|