KALRN

Gene Symbol KALRN
Entrez Gene 8997
Alt Symbol ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD
Species Human
Gene Type protein-coding
Description kalirin, RhoGEF kinase
Other Description huntingtin-associated protein interacting protein (duo)|kalirin|serine/threonine kinase with Dbl- and pleckstrin homology domains|serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Swissprots Q6ZN45 Q8TBQ5 A8MSI4 Q9NSZ4 C9JQ37 Q9Y2A5 O60229
Accessions EAW79410 EAW79414 EAW79415 EAW79416 EAW79417 EAW79418 EAW79419 EAW79420 EAW79421 EAW79422 EAW79423 O60229 AB011422 BAA76314 AI024603 AK022394 AK096580 AK123068 AK125979 BAC86373 AK126954 AK128223 AK131379 BAD18530 AK296657 BAG59254 AK311154 AK311581 AK314126 AL137629 CAB70850 BC026865 AAH26865 BC037924 BC058015 AAH58015 BC166705 AAI66705 BM930007 BQ345377 CB045666 DA756158 DB450617 HG496003 U94190 AAC15791 XM_006713810 XP_006713873 XM_006713811 XP_006713874 XM_006713812 XP_006713875 XM_006713813 XP_006713876 XM_006713814 XP_006713877 XM_006713815 XP_006713878 XM_006713817 XP_006713880 XM_011513279 XP_011511581 XM_011513280 XP_011511582 XM_011513281 XP_011511583 XM_011513282 XP_011511584 XM_011513283 XP_011511585 XM_011513284 XP_011511586 XM_011513285 XP_011511587 XM_011513286 XP_011511588 NM_001024660 NP_001019831 NM_003947 NP_003938 NM_007064 NP_008995 NR_028136
Function Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. {ECO:0000269|PubMed:10023074}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10023074}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10023074}. Note=Associated with the cytoskeleton.
Tissue Specificity Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. {ECO:0000269|PubMed:10023074}.

Duo (C-20) - sc-18592 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Duo (C-20): sc-18592. Western blot analysis of Duo expression in rat brain tissue extract.

Duo (H-300) - sc-366659 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Duo (H-300): sc-366659. Western blot analysis of Duo expression in A549 whole cell lysate (A) and human hippocampus tissue extract (B).

Anti-KALRN antibody - ab52012 from Abcam

Prices $380.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
ab52012 staining KALRN in adult brain tissue by Immunohistochemistry (paraffin embedded sections). Tissue was fixed with paraformaldehyde and a heat mediated antigen retrieval step performed using citrate buffer. Tissues were then blocked with 15% serum for 45 minutes at 20°C followed by incubation with the primary antibody, at a 1/250 dilution, for 24 hours at 4°C. A Biotin-conjugated rabbit anti-goat IgG was used as secondary antibody at a 1/250 dilution.Upper image: Un-treated.Lower image: Treated with peptide to KALRN.Counterstained with Hämalaun.See Abreview

Anti-KALRN antibody - ab110842 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KALRN / KALIRIN Antibody (aa21-33) - LS-C112735 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-KALRN / KALIRIN Antibody (C-Terminus) - LS-C144999 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KALRN / KALIRIN Antibody (C-Terminus) - LS-C153474 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KALRN / KALIRIN Antibody (aa895-940) - LS-C313745 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KALRN / KALIRIN Antibody (aa1650-1663) - LS-C55021 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (2 ug/ml) staining of Mouse Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-KALRN / KALIRIN Antibody (aa1591-1605) IHC-plus™ - LS-B137 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KALRN antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B137 concentration 5 ug/ml.

KALRN Antibody - NB100-41371 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: KALRN Antibody [NB100-41371] - (1.0ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

KALRN Antibody - 36360002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: KALRN Antibody [36360002]

KALRN Antibody - NBP1-88821 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: KALRN Antibody [NBP1-88821] - Staining of human prostate shows strong membranous positivity in glandular cells.

KALRN Antibody - NBP1-28479 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

KALRN Antibody - NBP1-02585 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: KALRN Antibody [NBP1-02585] - Staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

KALRN/Duo Polyclonal Antibody - bs-11861R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KALRN/Duo Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11861R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KALRN/Duo Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11861R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KALRN/Duo Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11861R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KALRN/Duo Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11861R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KALRN/Duo Polyclonal Antibody, Cy3 Conjugated - bs-11861R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KALRN/Duo Polyclonal Antibody, Cy5 Conjugated - bs-11861R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KALRN/Duo Polyclonal Antibody, Cy5.5 Conjugated - bs-11861R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KALRN/Duo Polyclonal Antibody, Cy7 Conjugated - bs-11861R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KALRN/Duo Polyclonal Antibody, FITC Conjugated - bs-11861R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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