| Gene Symbol |
FBXW10
|
| Entrez Gene |
10517
|
| Alt Symbol |
Fbw10, HREP, SM25H2, SM2SH2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and WD repeat domain containing 10
|
| Other Description |
F-box and WD-40 domain protein 10|F-box/WD repeat-containing protein 10|ubiquitin ligase specificity factor
|
| Swissprots |
Q9H0F0 C9JZD7 Q8TC00 C9JRY8 Q5XX13
|
| Accessions |
CBH19282 Q5XX13 AK310383 AL136822 CAB66756 AY729024 AAU43731 BC028364 AAH28364 BI828401 DB055860 XM_006721420 XP_006721483 XM_011523617 XP_011521919 XM_011523618 XP_011521920 XM_011523619 XP_011521921 XM_011523620 XP_011521922 XM_011523621 XP_011521923 XM_011523622 XP_011521924 XM_011523623 XP_011521925 XM_011523624 XP_011521926 XM_011523625 XP_011521927 XM_011523626 XP_011521928 XM_011523627 XP_011521929 XR_933968 NM_031456 NM_001267585 NP_001254514 NM_001267586 NP_001254515 NR_051988
|
| Function |
Probable substrate-recognition component of a SCF (SKP1- CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. {ECO:0000269|PubMed:20498703}.
|