| Gene Symbol |
NIN
|
| Entrez Gene |
51199
|
| Alt Symbol |
SCKL7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ninein (GSK3B interacting protein)
|
| Other Description |
glycogen synthase kinase 3 beta-interacting protein|hNinein|ninein|ninein centrosomal protein
|
| Swissprots |
Q9HAT7 Q9UH61 C9JSG2 Q5BKU3 Q8N4C6 Q6P0P6 Q9H5I6 Q9BWU6 C9JXL2 Q9HCK7 C9JSB6 A6NDB8 Q9C014 Q9C013 Q9C012 Q9HBY5 B7WPA3
|
| Accessions |
AAV37180 EAW65692 EAW65693 EAW65694 EAW65695 EAW65696 EAW65697 EAW65698 EAW65699 EAW65700 EAW65701 Q8N4C6 AA742651 AB046785 BAB13391 AF186776 AAG17027 AF212162 AAF23015 AF223937 AAK00628 AF223938 AAK00629 AF223939 AAK00630 AF302773 AAG33512 AK025652 AK026083 AK027054 BAB15640 AL359571 AW505195 AY027794 AAK27375 AY027795 AAK27376 AY027796 AAK27377 AY736182 AAU86898 AY736183 AAU86899 BC034708 AAH34708 BC065521 AAH65521 BC090932 AAH90932 BM721510 CB241926 CR993064 HG506189 XM_005267735 XP_005267792 XM_006720160 XP_006720223 XM_011536817 XP_011535119 XM_011536818 XP_011535120 XM_011536819 XP_011535121 XM_011536820 XP_011535122 XM_011536821 XP_011535123 XM_011536822 XP_011535124 XM_011536823 XP_011535125 XM_011536824 XP_011535126 NM_016350 NP_057434 NM_020921 NP_065972 NM_182944 NP_891989 NM_182946 NP_891991 NM_182945
|
| Function |
Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. {ECO:0000269|PubMed:15190203}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11004522, ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:12927815, ECO:0000269|PubMed:15190203}. Note=Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5. {ECO:0000269|PubMed:11004522, ECO:0000269|PubMed:11162463}.
|