Gene Symbol | MPP1 |
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Entrez Gene | 4354 |
Alt Symbol | AAG12, DXS552E, EMP55, MRG1, PEMP |
Species | Human |
Gene Type | protein-coding |
Description | membrane protein, palmitoylated 1, 55kDa |
Other Description | 55 kDa erythrocyte membrane protein|aging-associated gene 12|erythrocyte membrane protein p55|migration-related gene 1|p55|palmitoylated erythrocyte membrane protein |
Swissprots | B4DZV5 Q2TSB6 Q5J7V5 G3XAI1 Q00013 |
Accessions | AAA60060 AAD14835 EAW72655 EAW72656 EAW72657 EAW72658 EAW72659 EAW72660 Q00013 AK093702 AK223396 BAD97116 AK290246 BAF82935 AK303111 BAG64217 AK304538 BAG65337 AK310681 AK311541 AK312296 BAG35223 AK315957 BAH14328 AY423731 AAS00494 AY634686 AAV35469 BC002392 AAH02392 DA074686 DQ891247 ABM82173 DQ894572 ABM85498 M64925 AAA60059 XM_011531167 XP_011529469 XM_011531168 XP_011529470 XM_011531169 XP_011529471 NM_001166460 NP_001159932 NM_001166461 NP_001159933 NM_001166462 NP_001159934 NM_002436 NP_002427 |
Function | Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Lipid-anchor. Cell projection, stereocilium {ECO:0000250}. Note=Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). Colocalizes with NF2 in non- myelin-forming Schwann cells. {ECO:0000250}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:17584769}. |
p55 CRISPR/Cas9 KO Plasmid (h) - sc-409649 from Santa Cruz Biotechnology
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p55 HDR Plasmid (h) - sc-409649-HDR from Santa Cruz Biotechnology
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p55 Double Nickase Plasmid (h) - sc-409649-NIC from Santa Cruz Biotechnology
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p55 Double Nickase Plasmid (h2) - sc-409649-NIC-2 from Santa Cruz Biotechnology
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p55 CRISPR Activation Plasmid (h) - sc-409649-ACT from Santa Cruz Biotechnology
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p55 CRISPR Activation Plasmid (h2) - sc-409649-ACT-2 from Santa Cruz Biotechnology
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p55 Lentiviral Activation Particles (h) - sc-409649-LAC from Santa Cruz Biotechnology
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p55 Lentiviral Activation Particles (h2) - sc-409649-LAC-2 from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU056231 from Sigma-Aldrich
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MISSION® siRNA - SIHK1314 from Sigma-Aldrich
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MISSION® siRNA - SIHK1313 from Sigma-Aldrich
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MISSION® siRNA - SIHK1315 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14502 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14502 from Sigma-Aldrich
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MPP1 siRNA (Human) - CRH2957 from Cohesion Biosciences
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MPP1 RNAi - H00004354-R02 from Novus Biologicals
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shRNA set against Human MPP1 (NM_002436.3) - SHH343924 from Creative biogene
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p55 siRNA (h2) - sc-156153 from Santa Cruz Biotechnology
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p55 shRNA Plasmid (h2) - sc-156153-SH from Santa Cruz Biotechnology
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p55 shRNA (h2) Lentiviral Particles - sc-156153-V from Santa Cruz Biotechnology
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Human MPP1 siRNA - orb263459 from Biorbyt
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MPP1 shRNA Plasmid (Human) - CHH2957 from Cohesion Biosciences
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MPP1 miRNA 3'UTR clone - MiUTR3H-02967 from Creative biogene
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