| Gene Symbol |
PIP5K1C
|
| Entrez Gene |
23396
|
| Alt Symbol |
LCCS3, PIP5K-GAMMA, PIP5K1-gamma, PIP5Kgamma
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
|
| Other Description |
diphosphoinositide kinase|phosphatidylinositol 4-phosphate 5-kinase type-1 gamma|ptdIns(4)P-5-kinase 1 gamma|type I PIP kinase
|
| Swissprots |
O60331 C6GIJ8 Q7LE07 C6GIJ7 B7Z9E7
|
| Accessions |
AAC15471 AAC32904 EAW69295 EAW69296 O60331 AB011161 BAA25515 AK301309 BAG62861 AK315912 BAH14283 BC004149 BC011138 BC167798 AAI67798 DC389567 FJ965536 ACS73483 FJ965537 ACS73484 HY000479 R46767 XM_011527845 XP_011526147 XM_011527846 XP_011526148 XM_011527847 XP_011526149 XM_011527848 XP_011526150 XM_011527849 XP_011526151 XM_011527850 XP_011526152 XM_011527851 XP_011526153 XM_011527852 XP_011526154 XM_011527853 XP_011526155 NM_001195733 NP_001182662 NM_001300849 NP_001287778 NM_012398 NP_036530
|
| Function |
Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endomembrane system. Cytoplasm. Cell junction, focal adhesion. Cell junction, adherens junction. Cell projection, ruffle membrane. Cell projection, phagocytic cup. Cell projection, uropodium. Note=Detected in plasma membrane invaginations. Isoform 3 is detected in intracellular vesicle-like structures.
|
| Tissue Specificity |
Isoform 1 is strongly expressed in brain and also detected in heart and lung. Isoform 2 is strongly expressed in pancreas and liver and in lesser quantities in brain, heart, lung and kidney. Isoform 3 is detected in large amounts in heart and large intestine, is also present in lung, pancreas and thyroid, and to a lesser extent in brain, stomach and kidney. {ECO:0000269|PubMed:19548880}.
|
| Top Pathways |
Focal adhesion, Fc gamma R-mediated phagocytosis, Endocytosis, Choline metabolism in cancer, Inositol phosphate metabolism
|