PIP5K1C

Gene Symbol	PIP5K1C
Entrez Gene	23396
Alt Symbol	LCCS3, PIP5K-GAMMA, PIP5K1-gamma, PIP5Kgamma
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
Other Description	diphosphoinositide kinase|phosphatidylinositol 4-phosphate 5-kinase type-1 gamma|ptdIns(4)P-5-kinase 1 gamma|type I PIP kinase
Swissprots	O60331 C6GIJ8 Q7LE07 C6GIJ7 B7Z9E7
Accessions	AAC15471 AAC32904 EAW69295 EAW69296 O60331 AB011161 BAA25515 AK301309 BAG62861 AK315912 BAH14283 BC004149 BC011138 BC167798 AAI67798 DC389567 FJ965536 ACS73483 FJ965537 ACS73484 HY000479 R46767 XM_011527845 XP_011526147 XM_011527846 XP_011526148 XM_011527847 XP_011526149 XM_011527848 XP_011526150 XM_011527849 XP_011526151 XM_011527850 XP_011526152 XM_011527851 XP_011526153 XM_011527852 XP_011526154 XM_011527853 XP_011526155 NM_001195733 NP_001182662 NM_001300849 NP_001287778 NM_012398 NP_036530
Function	Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane
Subcellular Location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endomembrane system. Cytoplasm. Cell junction, focal adhesion. Cell junction, adherens junction. Cell projection, ruffle membrane. Cell projection, phagocytic cup. Cell projection, uropodium. Note=Detected in plasma membrane invaginations. Isoform 3 is detected in intracellular vesicle-like structures.
Tissue Specificity	Isoform 1 is strongly expressed in brain and also detected in heart and lung. Isoform 2 is strongly expressed in pancreas and liver and in lesser quantities in brain, heart, lung and kidney. Isoform 3 is detected in large amounts in heart and large intestine, is also present in lung, pancreas and thyroid, and to a lesser extent in brain, stomach and kidney. {ECO:0000269|PubMed:19548880}.
Top Pathways	Focal adhesion, Fc gamma R-mediated phagocytosis, Endocytosis, Choline metabolism in cancer, Inositol phosphate metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PIP5KI gamma full length protein - ab161623 from Abcam Category Protein Source Wheat germ Species Human

Human PIP5KI gamma protein fragment - ab161624 from Abcam Category Protein Source Wheat germ Species Human

PIP5K1C Antibody Blocking Peptide - LS-E9447 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIP5K1C Antibody Blocking Peptide - LS-E9448 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PIP5K1C Protein - H00023396-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PIP5K1C Protein - H00023396-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PIP5K1C Peptide - P3022 from Novus Biologicals Category Peptide Species Human

PIP5K1C Peptide - P3021 from Novus Biologicals Category Peptide Species Human

PIP5K1C-Antibody-C-term-Blocking-Peptide - BP14176b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIP5KI-gamma-PIP5K1G-Antibody-C-term-Blocking-peptide - BP8039b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIP5KI-gamma-PIP5K1G-Antibody-N-term-Blocking-peptide - BP8039a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIP5K1C peptide - orb218435 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse

PIP5K1C Blocking Peptide - abx063766 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

PIP5K1C - H00023396-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PIP5K1C - H00023396-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PIP5K1C - H00023396-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PIP5K1C - H00023396-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human phosphatidylinositol-4-phosphate 5-kinase, type I, GST-tagged - PIP5K1C-1083H from Creative Biomart Category Protein Species Human

Recombinant Human PIP5K1C (Active), GST-tagged - PIP5K1C-1462H from Creative Biomart Category Protein Source Sf9 Cells Species Human

PIP5K1γ Protein, active, 10 µg - 14-845 from EMD Millipore Category Protein Prices $730.00 Sizes 10 µg also available in 250μg size as catalog # 14-845m - call for pricing and availability. Source Expressed by baculovirus in Sf21 insect cells

PIP5K1γ Protein, active, 250 µg - 14-845M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-845) and in bulk (cat# 14-845-K) Source Expressed by baculovirus in Sf21 insect cells

PIP5K1C Blocking Peptide - CBP2572 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

PIP5KIγ Peptide - BS5857P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma(PIP5K1C) - CSB-YP018027HU CSB-EP018027HU CSB-BP018027HU CSB-MP018027HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PIP5K1C - TP315828 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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