| Gene Symbol |
NSMF
|
| Entrez Gene |
26012
|
| Alt Symbol |
HH9, NELF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NMDA receptor synaptonuclear signaling and neuronal migration factor
|
| Other Description |
nasal embryonic LHRH factor|nasal embryonic luteinizing hormone-releasing hormone factor
|
| Swissprots |
Q9NPS3 Q96SY1 Q9NPM4 Q8N2M2 Q6X4V9 Q2TB96 Q9NPP3 Q6X4V8 Q6X4W1 Q6X4V7
|
| Accessions |
CAF85849 EAW88390 EAW88391 EAW88392 EAW88393 EAW88394 Q6X4W1 AJ420418 AK027474 BAB55139 AK074602 BAC11086 AK292030 BAF84719 AK294320 BAG57594 AK303703 BAG64688 AK303976 BAH14089 AK316046 BAH14417 AL117660 CAB56031 AL389944 CAB97524 AL389945 CAB97542 AL389946 CAB97525 AW072125 AY255128 AAP83576 AY255129 AAP83577 AY255130 AAP83578 AY255131 AAP83579 AY255132 AAP83580 BC004318 AAH04318 BC016862 AAH16862 BC072412 AAH72412 BC110498 AAI10499 BM023184 CN306732 XM_005266061 XP_005266118 XM_005266062 XP_005266119 XM_011518496 XP_011516798 XM_011518497 XP_011516799 NM_001130969 NP_001124441 NM_001130970 NP_001124442 NM_001130971 NP_001124443 NM_001178064 NP_001171535 NM_015537 NP_056352
|
| Function |
Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. {ECO:0000269|PubMed:20025934}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20025934}. Nucleus envelope {ECO:0000250}. Nucleus membrane {ECO:0000250}. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:20025934}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:20025934}; Peripheral membrane protein {ECO:0000269|PubMed:20025934}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Membrane {ECO:0000250}. Note=Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium. Associates with transcriptionally active chromatin regions. Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a
|
| Tissue Specificity |
Highly expressed in adult and fetal brain. Weakly expressed in heart, liver, spleen, testis, small intestine, skeletal muscle, peripheral white blood cells and kidney. {ECO:0000269|PubMed:15362570, ECO:0000269|PubMed:20025934}.
|