| Gene Symbol |
KLF8
|
| Entrez Gene |
11279
|
| Alt Symbol |
BKLF3, ZNF741
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Kruppel-like factor 8
|
| Other Description |
Krueppel-like factor 8|basic krueppel-like factor 3|basic kruppel-like factor 3|zinc finger protein 741
|
| Swissprots |
E7EQQ8 Q9UGC4 Q5HYQ5 Q5JXP7 Q2M246 Q6MZJ7 B4DJN3 L0R4U2 Q59GV5 O95600 L0R3U8
|
| Accessions |
EAW93230 EAW93231 EAW93232 O95600 AB209004 BAD92241 AK054627 AK296156 BAG58895 BC031355 AAH31355 BC063276 BC105130 AAI05131 BC112109 AAI12110 BX098438 BX641066 CAE46033 EU446774 ABZ92303 HF546207 CCO02793 HF546208 CCO02794 HF546209 CCO02795 XM_005261977 XP_005262034 XM_005261978 XP_005262035 XM_005261979 XP_005262036 XM_006724575 XP_006724638 XM_006724576 XP_006724639 XM_011530759 XP_011529061 XM_011530760 XP_011529062 NM_001159296 NP_001152768 NM_007250 NP_009181
|
| Function |
Transcriptional repressor and activator. Binds to CACCC- boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). {ECO:0000269|PubMed:10756197, ECO:0000269|PubMed:12820964, ECO:0000269|PubMed:16617055}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16617055}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10756197}.
|