Gene Symbol | KLF8 |
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Entrez Gene | 11279 |
Alt Symbol | BKLF3, ZNF741 |
Species | Human |
Gene Type | protein-coding |
Description | Kruppel-like factor 8 |
Other Description | Krueppel-like factor 8|basic krueppel-like factor 3|basic kruppel-like factor 3|zinc finger protein 741 |
Swissprots | E7EQQ8 Q9UGC4 Q5HYQ5 Q5JXP7 Q2M246 Q6MZJ7 B4DJN3 L0R4U2 Q59GV5 O95600 L0R3U8 |
Accessions | EAW93230 EAW93231 EAW93232 O95600 AB209004 BAD92241 AK054627 AK296156 BAG58895 BC031355 AAH31355 BC063276 BC105130 AAI05131 BC112109 AAI12110 BX098438 BX641066 CAE46033 EU446774 ABZ92303 HF546207 CCO02793 HF546208 CCO02794 HF546209 CCO02795 XM_005261977 XP_005262034 XM_005261978 XP_005262035 XM_005261979 XP_005262036 XM_006724575 XP_006724638 XM_006724576 XP_006724639 XM_011530759 XP_011529061 XM_011530760 XP_011529062 NM_001159296 NP_001152768 NM_007250 NP_009181 |
Function | Transcriptional repressor and activator. Binds to CACCC- boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). {ECO:0000269|PubMed:10756197, ECO:0000269|PubMed:12820964, ECO:0000269|PubMed:16617055}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16617055}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10756197}. |
KLF8 CRISPR/Cas9 KO Plasmid (h) - sc-403571 from Santa Cruz Biotechnology
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KLF8 HDR Plasmid (h) - sc-403571-HDR from Santa Cruz Biotechnology
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KLF8 Double Nickase Plasmid (h) - sc-403571-NIC from Santa Cruz Biotechnology
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KLF8 Double Nickase Plasmid (h2) - sc-403571-NIC-2 from Santa Cruz Biotechnology
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KLF8 CRISPR Activation Plasmid (h) - sc-403571-ACT from Santa Cruz Biotechnology
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KLF8 CRISPR Activation Plasmid (h2) - sc-403571-ACT-2 from Santa Cruz Biotechnology
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KLF8 Lentiviral Activation Particles (h) - sc-403571-LAC from Santa Cruz Biotechnology
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KLF8 Lentiviral Activation Particles (h2) - sc-403571-LAC-2 from Santa Cruz Biotechnology
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KLF8 siRNA (h) - sc-75390 from Santa Cruz Biotechnology
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KLF8 shRNA Plasmid (h) - sc-75390-SH from Santa Cruz Biotechnology
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KLF8 shRNA (h) Lentiviral Particles - sc-75390-V from Santa Cruz Biotechnology
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KLF8 RNAi - H00011279-R01 from Novus Biologicals
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MISSION® esiRNA - EHU086421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11256 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11256 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05505 from Sigma-Aldrich
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KLF8 siRNA (Human) - CRH7734 from Cohesion Biosciences
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shRNA set against Human KLF8 (NM_007250.4) - SHH325879 from Creative biogene
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KLF8 shRNA Plasmid (Human) - CHH7734 from Cohesion Biosciences
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KLF8 miRNA 3'UTR clone - MiUTR4H-TG04831 from Creative biogene
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