Disc1

Gene Symbol Disc1
Entrez Gene 244667
Alt Symbol -
Species Mouse
Gene Type protein-coding
Description disrupted in schizophrenia 1
Other Description disrupted in schizophrenia 1 homolog
Swissprots Q8CHP2 Q8CF87 Q7TQ21 Q811T9 Q8CHP1 Q8CF88
Accessions EDL11792 EDL11793 Q811T9 AF513723 AAN77091 AF513724 AAN77092 AJ506179 CAD44629 AJ506180 CAD44630 AY177673 AAO19641 AY320287 AAP83943 BC148606 AAI48607 XM_006531021 XP_006531084 XM_011248387 XP_011246689 XM_011248388 XP_011246690 NM_170596 NM_174853 NP_777278 NM_174854 NP_777279
Function Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. {ECO:0000269|PubMed:17825401, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360, ECO:0000269|PubMed
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with PCNT at the centrosome. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. {ECO:0000250}.
Tissue Specificity Expressed in granule cell precursors within the dentate migratory stream during the first week of postnatal life and in differentiated granule cells of the hippocampus (at protein level). Expressed in dentate gyrus, hippocampus and in the olfactory bulb. {ECO:0000269|PubMed:17825401, ECO:0000269|PubMed:19502360}.

DISC-1 (C-20) - sc-47985 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DISC-1 (C-20): sc-47985. Western blot analysis of DISC-1 expression in non-transfected 293T: sc-117752 (A) and mouse DISC-1 transfected 293T: sc-178524 (B) whole cell lysates.

DISC-1 (M-45) - sc-134506 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DISC-1 (M-45): sc-134506. Western blot analysis of DISC-1 expression in BC<sub>3</sub>H1 whole cell lysate.

DISC-1 (N-16) - sc-47990 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DISC-1 (N-16): sc-47990. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing punctate cytoplasmic localization.

Anti-DISC1 antibody - ab55810 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DISC1 antibody - Carboxyterminal end - ab55807 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

DISC1 Antibody - NB110-40775 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: DISC1 Antibody [NB110-40775] - DISC1 antibody was tested in PC-12 cells at 1:100 with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 549 (red).

DISC1 Antibody [DyLight 550] - NB110-40775R from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DISC1 Antibody [DyLight 488] - NB110-40775G from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DISC1 Antibody [Biotin] - NB110-40775B from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DISC1 Antibody [HRP] - NB110-40775H from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DISC1 Antibody [DyLight 650] - NB110-40775C from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DISC1 Antibody [FITC] - NB110-40775F from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DISC1 Antibody [DyLight 405] - NB110-40775V from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DISC1 Antibody [Alexa Fluor (R) 700] - NB110-40775AF700 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

DISC1 Antibody [Alexa Fluor (R) 647] - NB110-40775AF647 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

DISC1 Antibody [Alexa Fluor (R) 488] - NB110-40775AF488 from Novus Biologicals

Prices $329.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

DISC1 Antibody [Alexa Fluor (R) 405] - NB110-40775AF405 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Anti -DISC1 (Disrupted in Schizophrenia 1, RP4-730B13.1, KIAA0457, SCZD9) - D8066-83B from USBiological Life Science

Host Rabbit
Clonality Polyclonal

DISC1 antibody - PAB5882 from Acris Antibodies

Prices $420.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

DISC1 antibody - PAB5883 from Acris Antibodies

Prices $420.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

DISC1 antibody - PAB12144 from Acris Antibodies

Prices $500.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Staining of Disc1 on mouse brain neurons, glial cells, and white matter using Disc1 polyclonal antibody ( Cat # PAB12144 ).

Rabbit Anti-Human DISC1 - DS-PB-02450 from RayBiotech

Host Rabbit

DISC1 Antibody - PA1-46164 from Thermo Fisher Scientific

Prices $354.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry staining of neurons, glial cells, and white matter. Mouse brain, 40X

DISC1 Polyclonal Antibody, DyLight 650 - PA5-22841 from Thermo Fisher Scientific

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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