| Gene Symbol |
Disc1
|
| Entrez Gene |
244667
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
disrupted in schizophrenia 1
|
| Other Description |
disrupted in schizophrenia 1 homolog
|
| Swissprots |
Q8CHP2 Q8CF87 Q7TQ21 Q811T9 Q8CHP1 Q8CF88
|
| Accessions |
EDL11792 EDL11793 Q811T9 AF513723 AAN77091 AF513724 AAN77092 AJ506179 CAD44629 AJ506180 CAD44630 AY177673 AAO19641 AY320287 AAP83943 BC148606 AAI48607 XM_006531021 XP_006531084 XM_011248387 XP_011246689 XM_011248388 XP_011246690 NM_170596 NM_174853 NP_777278 NM_174854 NP_777279
|
| Function |
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. {ECO:0000269|PubMed:17825401, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360, ECO:0000269|PubMed
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with PCNT at the centrosome. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in granule cell precursors within the dentate migratory stream during the first week of postnatal life and in differentiated granule cells of the hippocampus (at protein level). Expressed in dentate gyrus, hippocampus and in the olfactory bulb. {ECO:0000269|PubMed:17825401, ECO:0000269|PubMed:19502360}.
|