JAK3

Gene Symbol	JAK3
Entrez Gene	3718
Alt Symbol	JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Species	Human
Gene Type	protein-coding
Description	Janus kinase 3
Other Description	Janus kinase 3 (a protein tyrosine kinase, leukocyte)|leukocyte Janus kinase|tyrosine-protein kinase JAK3
Swissprots	Q9Y6S2 Q99699 Q8N1E8 Q13259 Q13260 P52333 Q13611
Accessions	AAC50950 AAD22741 AAM44860 EAW84637 EAW84638 EAW84639 EAW84640 P52333 AK296383 BAG59055 AK304392 BAG65227 BC028068 AAH28068 BF512748 BM561964 DA405504 U08340 AAA17743 U09607 AAA19626 U31317 AAC50225 U31601 AAC50226 U57096 AAC50542 XM_005259896 XP_005259953 XM_006722745 XP_006722808 XM_011527990 XP_011526292 XM_011527991 XP_011526293 XR_430137 NM_000215 NP_000206
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both
Subcellular Location	Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity	In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. {ECO:0000269|PubMed:7535338}.
Top Pathways	HTLV-I infection, Chemokine signaling pathway, Measles, Jak-STAT signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phosphotyrosine JAK3 / Tyrosine-protein Kinase JAK3 ELISA Kit - RAB0972 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human Janus Kinase 3 ELISA Kit - abx152077 from Abbexa Category ELISA Kit Sensitivity 0.066 ng/ml Range 0.156 ng/ml - 10 ng/ml

Janus Kinase 3 (JAK3), Human, ELISA Kit - SEF493Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.066ng/mL Range 0.156-10ng/mL

Tyrosine-protein kinase JAK3 (JAK3), Human, ELISA Kit - CSB-EL011932HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Tyrosine-protein kinase JAK3, JAK3, Human, ELISA Kit - E0425h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

JAK3 Colorimetric Cell-Based ELISA Kit - CB5386 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

JAK3 (Phospho-Tyr785) Colorimetric Cell-Based ELISA Kit - CBP1428 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human JAK3(Janus Kinase 3) ELISA Kit - E-EL-H5559 from Elabscience Category ELISA Kit Sensitivity 46.88 pg/mL Range 78.13—5000 pg/mL

Janus Kinase 3, ELISA Kit - MBS093966 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase 3, ELISA Kit - MBS066862 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase 3, ELISA Kit - MBS062583 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase 3, ELISA Kit - MBS052619 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase 3, ELISA Kit - MBS051626 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase 3, ELISA Kit - MBS058343 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus Kinase 3, ELISA Kit - MBS072703 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Janus kinase 3 (a protein tyrosine kinase, leukocyte) , ELISA Kit - MBS913479 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Janus Kinase 3 (JAK3), ELISA Kit - MBS2000227 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.066ng/mL. Range 0.156-10ng/mL

ELISA Kit for Janus Kinase 3 (JAK3) - SEF493Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.066ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Janus Kinase 3 (JAK3) - SEF493Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 6.2pg/mL. Range 15.63-1000pg/mL The standard curve concentrations used for the ELISA’s were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.63pg/mL

Human Tyrosine-protein kinase JAK3(JAK3) ELISA kit - CSB-EL011932HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml. Range 25 pg/ml-1600 pg/ml

ELISA Kit for Janus Kinase 3 (JAK3) - SEF493Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.066ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Janus Kinase 3 (JAK3) ELISA Kit - EKU05416 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.066 ng/mL Range 0.156-10 ng/mL

JAK3 ELISA Kit - DEIA-XYA1075 from Creative Diagnostics Category ELISA Kit

JAK3 (Phospho-Tyr785) ELISA Kit - DEIA-XYA1076 from Creative Diagnostics Category ELISA Kit

Human JAK3 ELISA Kit - orb371130 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 0.156-10ng/mL Detection low threshold: 0.066ng/mL

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