JAK3

Gene Symbol	JAK3
Entrez Gene	3718
Alt Symbol	JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Species	Human
Gene Type	protein-coding
Description	Janus kinase 3
Other Description	Janus kinase 3 (a protein tyrosine kinase, leukocyte)|leukocyte Janus kinase|tyrosine-protein kinase JAK3
Swissprots	Q9Y6S2 Q99699 Q8N1E8 Q13259 Q13260 P52333 Q13611
Accessions	AAC50950 AAD22741 AAM44860 EAW84637 EAW84638 EAW84639 EAW84640 P52333 AK296383 BAG59055 AK304392 BAG65227 BC028068 AAH28068 BF512748 BM561964 DA405504 U08340 AAA17743 U09607 AAA19626 U31317 AAC50225 U31601 AAC50226 U57096 AAC50542 XM_005259896 XP_005259953 XM_006722745 XP_006722808 XM_011527990 XP_011526292 XM_011527991 XP_011526293 XR_430137 NM_000215 NP_000206
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both
Subcellular Location	Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity	In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. {ECO:0000269|PubMed:7535338}.
Top Pathways	HTLV-I infection, Chemokine signaling pathway, Measles, Jak-STAT signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human JAK3 protein fragment - ab89756 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human JAK3 protein fragment - ab89982 from Abcam Category Protein Prices $343.00 Sizes 10 µg Source Baculovirus Species Human

Human JAK3 full length protein - ab131814 from Abcam Category Protein Source Wheat germ Species Human

Jak3 Recombinant Protein - H00003718-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Jak3 Recombinant Protein - P4709 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

JAK3 Blocking Peptide - 33R-4519 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Janus Kinase 3 Protein - abx067582 from Abbexa Category Protein Source E.coli Species Human

Tyrosine-protein kinase JAK3 - H00003718-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Tyrosine-protein kinase JAK3 - H00003718-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Tyrosine-protein kinase JAK3 - P4709 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

Tyrosine-protein kinase JAK3 - P5724 from Acris Antibodies Category Protein Prices $1,180.00 Sizes 5 µg Species Human

Recombinant Human JAK3 extracellular domain, Transfected HEK293 Cell Lysate - 230-10078-100 from RayBiotech Category Protein Prices $153.50 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Janus Kinase 3 (JAK3), Human - 20-9080 from ARP American Research Products Category Protein Prices $509.00 Sizes 50 µg Source E.coli Species Human

JAK3 fusion protein - Ag5773 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

JAK3 fusion protein - ag4298 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant JAK3 protein - 31182 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source Baculovirus Species Human

Jak3, Active Human Recombinant Protein - GWB-BE5317 from Genway Biotech Category Protein Prices $410.00 Sizes 10 µg Species Human

Recombinant Human Janus Kinase 3, GST-tagged, Active - JAK3-337H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus .

Recombinant Human Janus Kinase 3, GST-His - JAK3-2657H from Creative Biomart Category Protein Source S.frugiperda.

Recombinant Human JAK3 - JAK3-27631TH from Creative Biomart Category Protein Species Human

Recombinant Human JAK3 - JAK3-29667TH from Creative Biomart Category Protein

Recombinant Human JAK3 - JAK3-466H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Janus Kinase 3 (JAK3) - RPF493Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Janus Kinase 3 (JAK3) - RPF493Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Janus Kinase 3 (JAK3) - RPF493Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

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