| Gene Symbol | JAK3 |
|---|---|
| Entrez Gene | 3718 |
| Alt Symbol | JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK |
| Species | Human |
| Gene Type | protein-coding |
| Description | Janus kinase 3 |
| Other Description | Janus kinase 3 (a protein tyrosine kinase, leukocyte)|leukocyte Janus kinase|tyrosine-protein kinase JAK3 |
| Swissprots | Q9Y6S2 Q99699 Q8N1E8 Q13259 Q13260 P52333 Q13611 |
| Accessions | AAC50950 AAD22741 AAM44860 EAW84637 EAW84638 EAW84639 EAW84640 P52333 AK296383 BAG59055 AK304392 BAG65227 BC028068 AAH28068 BF512748 BM561964 DA405504 U08340 AAA17743 U09607 AAA19626 U31317 AAC50225 U31601 AAC50226 U57096 AAC50542 XM_005259896 XP_005259953 XM_006722745 XP_006722808 XM_011527990 XP_011526292 XM_011527991 XP_011526293 XR_430137 NM_000215 NP_000206 |
| Function | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both |
| Subcellular Location | Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. |
| Tissue Specificity | In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. {ECO:0000269|PubMed:7535338}. |
| Top Pathways | HTLV-I infection, Chemokine signaling pathway, Measles, Jak-STAT signaling pathway, Viral carcinogenesis |