Gene Symbol | THG1L |
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Entrez Gene | 54974 |
Alt Symbol | ICF45, IHG-1 |
Species | Human |
Gene Type | protein-coding |
Description | tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) |
Other Description | induced by high glucose-1|interphase cytoplasmic foci protein 45|probable tRNA(His) guanylyltransferase |
Swissprots | Q53G12 Q7L5R3 Q9NWX6 D3DQJ5 Q9H0S2 |
Accessions | EAW61590 EAW61591 Q9NWX6 AF086486 AK000553 BAA91249 AK021663 BAB13870 AK023355 BAB14540 AK223119 BAD96839 AK304590 BAG65378 AL136669 CAB66604 AY463216 AAS21134 BC001523 AAH01523 BC001852 AAH01852 BC023521 AAH23521 CR533503 CAG38534 XM_005265939 XP_005265996 XM_011534591 XP_011532893 XM_011534592 XP_011532894 NM_017872 NP_060342 |
Function | Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. {ECO:0000269|PubMed:21059936}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15459185}. Note=Found near the nuclear membrane. |
Tissue Specificity | Expressed in many tissues. {ECO:0000269|PubMed:15459185}. |
ICF45 CRISPR/Cas9 KO Plasmid (h) - sc-408529 from Santa Cruz Biotechnology
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ICF45 HDR Plasmid (h) - sc-408529-HDR from Santa Cruz Biotechnology
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ICF45 Double Nickase Plasmid (h) - sc-408529-NIC from Santa Cruz Biotechnology
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ICF45 Double Nickase Plasmid (h2) - sc-408529-NIC-2 from Santa Cruz Biotechnology
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ICF45 CRISPR Activation Plasmid (h) - sc-408529-ACT from Santa Cruz Biotechnology
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ICF45 CRISPR Activation Plasmid (h2) - sc-408529-ACT-2 from Santa Cruz Biotechnology
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ICF45 Lentiviral Activation Particles (h) - sc-408529-LAC from Santa Cruz Biotechnology
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ICF45 Lentiviral Activation Particles (h2) - sc-408529-LAC-2 from Santa Cruz Biotechnology
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ICF45 siRNA (h) - sc-91730 from Santa Cruz Biotechnology
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ICF45 shRNA Plasmid (h) - sc-91730-SH from Santa Cruz Biotechnology
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ICF45 shRNA (h) Lentiviral Particles - sc-91730-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU006731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21311 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02863 from Sigma-Aldrich
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THG1L siRNA (Human) - CRJ0373 from Cohesion Biosciences
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THG1L - MBS8229410 from MyBioSource
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shRNA set against Human THG1L (NM_017872.3) - SHH426868 from Creative biogene
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shRNA set against Human THG1L(NM_017872.3) - SHL069102 from Creative biogene
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Human THG1L siRNA - orb270874 from Biorbyt
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THG1L shRNA Plasmid (Human) - CHJ0373 from Cohesion Biosciences
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THG1L miRNA 3'UTR clone - MiUTR1H-10379 from Creative biogene
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