| Gene Symbol |
GCGR
|
| Entrez Gene |
2642
|
| Alt Symbol |
GGR, GL-R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glucagon receptor
|
| Other Description |
-
|
| Swissprots |
Q2M3M5 P47871
|
| Accessions |
AAA35897 CAB52383 EAW89684 P47871 AK307234 AK314247 BC104854 AAI04855 BC112041 AAI12042 BJ997148 DA639395 L20316 AAA53628 U03469 AAC52063 XM_006722277 XP_006722340 XM_011523539 XP_011521841 XM_011523540 XP_011521842 NM_000160 NP_000151
|
| Function |
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}; Multi-pass membrane protein {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}. Note=Is rapidly internalized after ligand-binding.
|
| Top Pathways |
Glucagon signaling pathway, Neuroactive ligand-receptor interaction
|