GCGR

Gene Symbol	GCGR
Entrez Gene	2642
Alt Symbol	GGR, GL-R
Species	Human
Gene Type	protein-coding
Description	glucagon receptor
Other Description	-
Swissprots	Q2M3M5 P47871
Accessions	AAA35897 CAB52383 EAW89684 P47871 AK307234 AK314247 BC104854 AAI04855 BC112041 AAI12042 BJ997148 DA639395 L20316 AAA53628 U03469 AAC52063 XM_006722277 XP_006722340 XM_011523539 XP_011521841 XM_011523540 XP_011521842 NM_000160 NP_000151
Function	G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}; Multi-pass membrane protein {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}. Note=Is rapidly internalized after ligand-binding.
Top Pathways	Glucagon signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Glucagon Receptor peptide - ab140072 from Abcam Category Peptide Prices $176.00 Sizes 200 µg

GCGR / Glucagon Receptor Antibody Blocking Peptide - LS-E28925 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GCGR / Glucagon Receptor Antibody Blocking Peptide - LS-E28926 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GCGR / Glucagon Receptor Antibody Blocking Peptide - LS-E28927 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GCGR / Glucagon Receptor Antibody Blocking Peptide - LS-E28929 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GCGR / Glucagon Receptor Blocking Peptide - LS-E29397 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GCGR / Glucagon Receptor Antibody Blocking Peptide - LS-E29399 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GCGR / Glucagon Receptor Antibody Blocking Peptide - LS-E29400 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GCGR / Glucagon Receptor Antibody Blocking Peptide - LS-E26364 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCGR / Glucagon Receptor Antibody Blocking Peptide - LS-E35701 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GCGR-Antibody-Center-Blocking-Peptide - BP8908c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Glucogon receptor blocking peptide - GTX89041-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Mouse Glucagon receptor (OPCA00095) - OPCA00095 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Mouse

Glucagon Receptor Blocking Peptide - abx062659 from Abbexa Category Peptide Species Human, Rat

Glucogon Receptor Peptide - AC21-1199-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Glucagon Receptor Peptide - 46-667P from ProSci Category Peptide

GCGR fusion protein - ag13622 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Glucagon Receptor Blocking Peptide - CBP1465 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Rat

Glucagon Receptor (K136) Peptide - BS2718P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Glucogon receptor, Peptide - MBS425484 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

ChemiScreen™ Recombinant Human Glucagon Receptor Membrane Preparation - HTS112M from EMD Millipore Prices $596.00 Sizes 200 units Species Human

GCGR Peptide, Human - M34GP06160H from Creative Peptides Category Peptide Source Synthetic. Species Human

Glucagon R/GCGR Recombinant Protein Antigen - NBP2-55921PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Glucagon receptor (GCGR), Recombinant Protein - MBS7015470 from MyBioSource Category Protein Prices $1,255.00, $2,240.00, $3,450.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Glucagon receptor (GCGR), Recombinant Protein - MBS966020 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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