| Gene Symbol | MMP16 |
|---|---|
| Entrez Gene | 4325 |
| Alt Symbol | C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP |
| Species | Human |
| Gene Type | protein-coding |
| Description | matrix metallopeptidase 16 (membrane-inserted) |
| Other Description | MMP-16|MT-MMP 3|MT3MMP|MTMMP3|Putative transmembrane protein C8orf57|matrix metalloproteinase-16|membrane-type matrix metalloproteinase 3|membrane-type-3 matrix metalloproteinase |
| Swissprots | Q52H48 P51512 Q14824 B2RAN7 |
| Accessions | AAX84515 EAW91651 EAW91652 P51512 AB009303 BAA23742 AK314274 BAG36934 AL136588 CAB66523 AL832595 BC069500 AAH69500 BC075004 AAH75004 BC075005 AAH75005 D83646 BAA12022 D83647 BAA12023 D85511 BAA22226 DA575789 DR002176 U79292 XM_011517039 XP_011515341 XM_011517040 XP_011515342 XM_011517041 XP_011515343 XM_011517042 XP_011515344 XR_928334 NM_005941 NP_005932 NM_022564 NM_032297 |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. {ECO:0000269|PubMed:11278606}. |
| Subcellular Location | Isoform Long: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Note=Localized at the cell surface of melanoma cells. |
| Tissue Specificity | Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary. |
| Top Pathways | MicroRNAs in cancer |