Gene Symbol | MMP16 |
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Entrez Gene | 4325 |
Alt Symbol | C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP |
Species | Human |
Gene Type | protein-coding |
Description | matrix metallopeptidase 16 (membrane-inserted) |
Other Description | MMP-16|MT-MMP 3|MT3MMP|MTMMP3|Putative transmembrane protein C8orf57|matrix metalloproteinase-16|membrane-type matrix metalloproteinase 3|membrane-type-3 matrix metalloproteinase |
Swissprots | Q52H48 P51512 Q14824 B2RAN7 |
Accessions | AAX84515 EAW91651 EAW91652 P51512 AB009303 BAA23742 AK314274 BAG36934 AL136588 CAB66523 AL832595 BC069500 AAH69500 BC075004 AAH75004 BC075005 AAH75005 D83646 BAA12022 D83647 BAA12023 D85511 BAA22226 DA575789 DR002176 U79292 XM_011517039 XP_011515341 XM_011517040 XP_011515342 XM_011517041 XP_011515343 XM_011517042 XP_011515344 XR_928334 NM_005941 NP_005932 NM_022564 NM_032297 |
Function | Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. {ECO:0000269|PubMed:11278606}. |
Subcellular Location | Isoform Long: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Note=Localized at the cell surface of melanoma cells. |
Tissue Specificity | Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary. |
Top Pathways | MicroRNAs in cancer |
MMP16 peptide - ab41099 from Abcam
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MMP16 peptide - ab43114 from Abcam
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MMP16 peptide - ab44857 from Abcam
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MMP16 Antibody Blocking Peptide - LS-E2642 from LifeSpan Bioscience
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MMP16 Antibody Blocking Peptide - LS-E16985 from LifeSpan Bioscience
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Recombinant Human MMP-16/MT3-MMP Protein - P4927 from Novus Biologicals
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MMP16-Antibody-C-term-Blocking-peptide - BP13713b from Abgent, a WuXi AppTec company
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Recombinant Human MMP-16/MT3-MMP, CF - 1785-MP-010 from R&D Systems
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MMP16 peptide - orb219135 from Biorbyt
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MMP16 Blocking Peptide - 33R-1318 from Fitzgerald
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Human MMP16 Protein - abx067960 from Abbexa
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MMP16 Blocking Peptide - abx062166 from Abbexa
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MMP-16 - P4927 from Acris Antibodies
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MMP16 fusion protein - ag12186 from Proteintech Group
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MMP16 fusion protein - Ag12719 from Proteintech Group
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Recombinant Human MMP16, Catalytic Domain - MMP16-608H from Creative Biomart
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Recombinant Matrix Metalloproteinase 16 (MMP16) - RPB533Hu01 from Uscn Life Science Inc.
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MMP16 Blocking Peptide - CBP3272 from Cohesion Biosciences
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MMP-16 (T583) Peptide - BS1234P from Bioworld Technology
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Recombinant Matrix Metalloproteinase 16 (MMP16) - RPB533Hu01 from Cloud-clone
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Recombinant Human Matrix metalloproteinase-16(MMP16) - CSB-YP014663HU CSB-EP014663HU CSB-BP014663HU CSB-MP014663HU from Cusabio
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Recombinant Human MMP-16/MT3-MMP Protein, CF - 1785-MP from R&D Systems
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MMP16-Antibody-N-term-Blocking-Peptide - BP6200a from Abgent, a WuXi AppTec company
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MMP16 Peptide, Human - M34GP09596H from Creative Peptides
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MMP16 Recombinant Protein (OPCD05328) - OPCD05328 from Aviva Systems Biology
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