FBXO25
| Gene Symbol | FBXO25 |
|---|---|
| Entrez Gene | 26260 |
| Alt Symbol | FBX25 |
| Species | Human |
| Gene Type | protein-coding |
| Description | F-box protein 25 |
| Other Description | F-box only protein 25|F-box protein Fbx25 |
| Swissprots | Q9UKB8 Q8TCJ0 Q7Z4V4 Q6PJ83 |
| Accessions | EAW51450 EAW51451 EAW51452 EAW51453 EAW51454 EAW51455 Q8TCJ0 AA316216 AB070270 BAB85128 AF174605 AAF04526 AF419858 AAP97293 AI223050 AK302334 BAG63665 BC012143 BC020249 AAH20249 BC035555 BC050393 AAH50393 DQ586074 HQ447709 ADQ32194 XM_005266029 XP_005266086 XM_005266030 XP_005266087 XM_005266031 XP_005266088 XM_005266032 XP_005266089 XM_005266033 XP_005266090 XM_011534748 XP_011533050 XM_011534749 XP_011533051 NM_012173 NP_036305 NM_183420 NP_904356 NM_183421 NP_904357 |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:16278047, ECO:0000269|PubMed:18287534}. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1. |
| Tissue Specificity | Expressed in all brain tissue observed. {ECO:0000269|PubMed:16278047}. |
FBXO25 CRISPR/Cas9 KO Plasmid (h) - sc-405092 from Santa Cruz Biotechnology
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FBXO25 HDR Plasmid (h) - sc-405092-HDR from Santa Cruz Biotechnology
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FBXO25 Double Nickase Plasmid (h) - sc-405092-NIC from Santa Cruz Biotechnology
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FBXO25 Double Nickase Plasmid (h2) - sc-405092-NIC-2 from Santa Cruz Biotechnology
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FBXO25 CRISPR Activation Plasmid (h) - sc-405092-ACT from Santa Cruz Biotechnology
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FBXO25 CRISPR Activation Plasmid (h2) - sc-405092-ACT-2 from Santa Cruz Biotechnology
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FBXO25 Lentiviral Activation Particles (h) - sc-405092-LAC from Santa Cruz Biotechnology
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FBXO25 Lentiviral Activation Particles (h2) - sc-405092-LAC-2 from Santa Cruz Biotechnology
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FBXO25 siRNA (h) - sc-77570 from Santa Cruz Biotechnology
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FBXO25 shRNA Plasmid (h) - sc-77570-SH from Santa Cruz Biotechnology
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FBXO25 shRNA (h) Lentiviral Particles - sc-77570-V from Santa Cruz Biotechnology
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FBXO25 RNAi - H00026260-R02 from Novus Biologicals
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FBXO25 RNAi - H00026260-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN8543 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8543 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07844 from Sigma-Aldrich
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FBXO25 siRNA (Human) - CRH8785 from Cohesion Biosciences
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FBXO25 RNAi - H00026260-R03 from Novus Biologicals
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FBXO25 - MBS8218326 from MyBioSource
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shRNA set against Human Fbxo25 (NM_183421.1) - SHH293149 from Creative biogene
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shRNA set against Human FBXO25(NM_183420.1) - SHH052085 from Creative biogene
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shRNA set against Human FBXO25(NM_012173.3) - SHH052093 from Creative biogene
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shRNA set against Human FBXO25(NM_183421.1) - SHH052129 from Creative biogene
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shRNA set against Human FBXO25(NM_183420.1) - SHH052147 from Creative biogene
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FBXO25 shRNA Plasmid (Human) - CHH8785 from Cohesion Biosciences
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